PIAS4 SUMOylates PPARA with SUMO1

Stable Identifier
R-HSA-4341070
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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PIAS4 SUMOylates PPARA at lysine-185 with SUMO1 (Pourcet et al. 2010). SUMOylation decreases the transactivation activity of PPARA. SUMOylation is decreased in the presence of ligand of PPARA.
Literature References
PubMed ID Title Journal Year
19955185 SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR

Derudas, B, Glineur, C, Staels, B, Pineda-Torra, I, Pourcet, B

J. Biol. Chem. 2010
Participants
Participates
Catalyst Activity

SUMO transferase activity of PIAS4 [nucleoplasm]

Orthologous Events
Authored
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