PIAS4 SUMOylates PPARA with SUMO1

Stable Identifier
R-HSA-4341070
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PIAS4 SUMOylates PPARA at lysine-185 with SUMO1 (Pourcet et al. 2010). SUMOylation decreases the transactivation activity of PPARA. SUMOylation is decreased in the presence of ligand of PPARA.

Literature References
PubMed ID Title Journal Year
19955185 SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR

Pourcet, B, Pineda-Torra, I, Derudas, B, Staels, B, Glineur, C

J. Biol. Chem. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS4 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created