PIAS4 SUMOylates PPARA with SUMO1

Stable Identifier
R-HSA-4341070
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PIAS4 SUMOylates PPARA with SUMO1
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PIAS4 SUMOylates PPARA at lysine-185 with SUMO1 (Pourcet et al. 2010). SUMOylation decreases the transactivation activity of PPARA. SUMOylation is decreased in the presence of ligand of PPARA.
Literature References
PubMed ID Title Journal Year
19955185 SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR

Pourcet, B, Pineda-Torra, I, Derudas, B, Staels, B, Glineur, C

J. Biol. Chem. 2010
Participants
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Output
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as an event of
Catalyst Activity

SUMO transferase activity of PIAS4 [nucleoplasm]

Physical Entity
PIAS4 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS4 SUMOylates PPARA with SUMO1 (Bos taurus)
PIAS4 SUMOylates PPARA with SUMO1 (Caenorhabditis elegans)
PIAS4 SUMOylates PPARA with SUMO1 (Danio rerio)
PIAS4 SUMOylates PPARA with SUMO1 (Gallus gallus)
PIAS4 SUMOylates PPARA with SUMO1 (Mus musculus)
PIAS4 SUMOylates PPARA with SUMO1 (Rattus norvegicus)
PIAS4 SUMOylates PPARA with SUMO1 (Sus scrofa)
Authored
May, B  (2013-08-14)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-08-19)
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