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GAK [cytoplasmic vesicle membrane]
Stable Identifier
R-HSA-434203
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane
Synonyms
Cyclin G-associated kinase, GAK_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
trans-Golgi Network Vesicle Budding (Homo sapiens)
Golgi Associated Vesicle Biogenesis (Homo sapiens)
trans-Golgi Network Derived Vesicle Uncoating (Homo sapiens)
Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex [cytoplasmic vesicle membrane] (Homo sapiens)
Golgi-associated Vesicle Cargo [cytoplasmic vesicle membrane] (Homo sapiens)
GAK [cytoplasmic vesicle membrane] (Homo sapiens)
Golgi-associated Vesicle Cargo [cytoplasmic vesicle membrane] (Homo sapiens)
GAK [cytoplasmic vesicle membrane] (Homo sapiens)
trans-Golgi Network Vesicle Scission (Homo sapiens)
Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex [cytoplasmic vesicle membrane] (Homo sapiens)
Golgi-associated Vesicle Cargo [cytoplasmic vesicle membrane] (Homo sapiens)
GAK [cytoplasmic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14976 GAK
Gene Names
GAK, DNAJC26
Chain
initiator methionine:, chain:2-1311
Reference Genes
BioGPS Gene:2580 GAK
COSMIC (genes):GAK GAK
CTD Gene:2580 GAK
dbSNP Gene:2580 GAK
ENSEMBL:ENSG00000178950 GAK
HGNC:4113 GAK
Monarch:2580 GAK
NCBI Gene:2580 GAK
OMIM:602052 GAK
UCSC:O14976 GAK
Reference Transcript
RefSeq:NM_005255.3 GAK
RefSeq:NM_001318134.1 GAK
Other Identifiers
11721027_a_at
11754278_x_at
16973375
202281_PM_at
202281_at
2580
2756674
2756675
2756676
2756677
2756678
2756679
2756680
2756681
2756682
2756683
2756684
2756685
2756686
2756687
2756691
2756693
2756694
2756696
2756697
2756699
2756700
2756701
2756702
2756703
2756705
2756706
2756707
2756708
2756711
2756713
2756714
2756722
2756723
2756724
2756725
2756726
2756728
2756731
2756732
2756733
2756734
2756735
2756736
2756737
2756739
2756742
2756743
2756746
2756747
2756748
2756749
2756750
2756751
2756753
2756754
2756755
2756756
2756757
2756758
2756759
2756765
2756766
2756767
2756768
2756769
2756770
2756771
2756776
2756777
40225_PM_at
40225_at
8098789
A_23_P155700
A_24_P397150
A_33_P3254013
GE57429
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005737
GO:0005794
GO:0005829
GO:0005925
GO:0006457
GO:0006468
GO:0006898
GO:0007029
GO:0007030
GO:0010977
GO:0016020
GO:0016191
GO:0016192
GO:0016301
GO:0016740
GO:0030136
GO:0030276
GO:0030332
GO:0031410
GO:0031982
GO:0034067
GO:0043226
GO:0043231
GO:0046907
GO:0048268
GO:0048471
GO:0051085
GO:0051087
GO:0065003
GO:0070161
GO:0072318
GO:0072583
GO:0072659
GO:0090160
GO:0098793
GO:0106310
GO:0140096
GO:1905443
HMNXSV003030648
HMNXSV003035454
HMNXSV003048962
ILMN_1672906
ILMN_1701042
ILMN_1731268
ILMN_1813775
PH_hs_0009213
PH_hs_0038447
TC04000957.hg
g4885250_3p_s_at
Participates
as a candidate of
Golgi-associated Vesicle Cargo [cytoplasmic vesicle membrane] (Homo sapiens)
Other forms of this molecule
GAK [cytosol]
GAK [Golgi membrane]
Inferred To
GAK [cytoplasmic vesicle membrane]
(Bos taurus)
GAK [cytoplasmic vesicle membrane]
(Canis familiaris)
GAK [cytoplasmic vesicle membrane]
(Dictyostelium discoideum)
GAK [cytoplasmic vesicle membrane]
(Mus musculus)
GAK [cytoplasmic vesicle membrane]
(Sus scrofa)
SWA2 [cytoplasmic vesicle membrane]
(Saccharomyces cerevisiae)
Gak [cytoplasmic vesicle membrane]
(Rattus norvegicus)
gak [cytoplasmic vesicle membrane]
(Xenopus tropicalis)
dnj-25 [cytoplasmic vesicle membrane]
(Caenorhabditis elegans)
Cross References
ZINC - World Drugs
GAK_HUMAN
Guide to Pharmacology - Targets
2027
ENSEMBL
ENST00000314167
,
ENSP00000314499
,
ENST00000511163
,
ENSP00000421361
OpenTargets
ENSG00000178950
ZINC - FDA approved
GAK_HUMAN
ZINC - Substances
GAK_HUMAN
ZINC - Biogenic
GAK_HUMAN
ZINC target
O14976
PRO
O14976
GlyGen
O14976
PDB
4C58
,
4C57
,
4Y8D
,
4C59
,
5Y7Z
,
5Y80
,
4O38
ZINC - Investigational
GAK_HUMAN
HPA
ENSG00000178950-GAK
Pharos - Targets
O14976
ZINC - Predictions - Purchasable
GAK_HUMAN
HMDB Protein
HMDBP09468
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.793
11
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.763
9
UniProt:Q96FJ0 STAMBPL1
1
STAMBPL1 [cytosol]
(R-HSA-6783264)
0.643
3
UniProt:Q9NSE4 IARS2
1
IARS2 [mitochondrial matrix]
(R-HSA-379571)
0.527
2
UniProt:O95630 STAMBP
1
STAMBP [cytosol]
(R-HSA-5693063)
0.527
2
UniProt:Q9P296 C5AR2
1
C5AR2 [plasma membrane]
(R-HSA-964798)
0.527
2
UniProt:Q9NQ11 ATP13A2
1
ATP13A2 [lysosomal lumen]
(R-HSA-939762)
0.508
2
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