Reactome | OCRL [cytoplasmic vesicle membrane]

OCRL [cytoplasmic vesicle membrane]

Stable Identifier

R-HSA-434214

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytoplasmic vesicle membrane

Synonyms

Inositol polyphosphate 5-phosphatase OCRL-1, OCRL_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q01968 OCRL

Gene Names

OCRL, OCRL1

Chain

chain:1-901

Reference Genes

BioGPS Gene:4952 OCRL

COSMIC (genes):OCRL OCRL

CTD Gene:4952 OCRL

dbSNP Gene:4952 OCRL

ENSEMBL:ENSG00000122126 OCRL

HGNC:8108 OCRL

KEGG Gene (Homo sapiens):4952 OCRL

Monarch:4952 OCRL

NCBI Gene:4952 OCRL

OMIM:300535 OCRL

UCSC:Q01968 OCRL

Reference Transcript

Other Identifiers

0001400239

11717180_at

11717181_a_at

11755916_a_at

17106822

208316_s_at

34169_s_at

3990377

3990378

3990381

3990382

3990383

3990385

3990386

3990387

3990388

3990389

3990390

3990391

3990392

3990394

3990395

3990396

3990397

3990398

3990399

3990408

3990410

3990412

3990414

3990415

3990416

3990417

3990418

3990419

3990420

41227_at

4952

8169811

A_14_P121440

A_23_P170246

GO:0001701

GO:0001750

GO:0003674

GO:0004439

GO:0004445

GO:0005096

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005764

GO:0005768

GO:0005769

GO:0005773

GO:0005794

GO:0005795

GO:0005798

GO:0005802

GO:0005829

GO:0005886

GO:0005905

GO:0005929

GO:0005975

GO:0006629

GO:0006661

GO:0007165

GO:0008150

GO:0009056

GO:0009058

GO:0009790

GO:0016020

GO:0016787

GO:0016791

GO:0019899

GO:0022607

GO:0030030

GO:0030136

GO:0030234

GO:0030670

GO:0031410

GO:0031901

GO:0042995

GO:0043087

GO:0043226

GO:0043547

GO:0043647

GO:0044281

GO:0046855

GO:0046856

GO:0048365

GO:0048856

GO:0051056

GO:0052658

GO:0052659

GO:0052745

GO:0060271

GO:0061024

ILMN_1760855

ILMN_2382121

PH_hs_0022390

TC0X000616.hg

U57627_at

g13249984_3p_a_at

g13325071_3p_a_at

Participant Of

hasCandidate

Golgi-associated Vesicle Cargo [cytoplasmic vesicle membrane]

Other forms of this molecule

OCRL [Golgi membrane]

OCRL [plasma membrane]

OCRL [cytosol]

Inferred To

Dd5P4 [cytoplasmic vesicle membrane] (Dictyostelium discoideum)

ocrl-1 [cytoplasmic vesicle membrane] (Caenorhabditis elegans)

OCRL [cytoplasmic vesicle membrane] (Bos taurus)

OCRL [cytoplasmic vesicle membrane] (Canis familiaris)

OCRL [cytoplasmic vesicle membrane] (Gallus gallus)

OCRL [cytoplasmic vesicle membrane] (Sus scrofa)

OCRL [cytoplasmic vesicle membrane] (Xenopus tropicalis)

ocrl [cytoplasmic vesicle membrane] (Danio rerio)

Ocrl [cytoplasmic vesicle membrane] (Drosophila melanogaster)

Ocrl [cytoplasmic vesicle membrane] (Mus musculus)

Ocrl [cytoplasmic vesicle membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_000267.2, NP_001578.2

OpenTargets

ENSG00000122126

IntEnz

3.1.3.56

HPA

ENSG00000122126-OCRL

GeneCards

Q01968

Ensembl

ENSG00000122126, ENST00000371113, ENSP00000349635, ENSP00000360154, ENST00000357121

PRO

Q01968

Orphanet

16585

HMDB Protein

HMDBP01569

PDB

2QV2, 3QIS, 4CMN, 3QBT, 2KIE

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20340 RAB6A	8	RAB6A [Golgi membrane] (R-HSA-1604442) RAB6A [endoplasmic reticulum membrane] (R-HSA-8849253) RAB6A [secretory granule membrane] (R-HSA-6804970) RAB6A [plasma membrane] (R-HSA-6804981) RAB6A [cytosol] (R-HSA-6810979) GGC-RAB6A [cytosol] (R-HSA-8874052) GGC-RAB6A [trans-Golgi network membrane] (R-HSA-8876079) RAB6A [trans-Golgi network membrane] (R-HSA-6810981)	0.835	13
UniProt:P20339 RAB5A	6	RAB5A [endosome membrane] (R-HSA-452257) RAB5A [cytosol] (R-HSA-2201187) RAB5A [early endosome membrane] (R-HSA-2130175) GGC-RAB5A [cytosol] (R-HSA-8870432) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125)	0.799	11
UniProt:P63000 RAC1	6	RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.556	3
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.534	2
UniProt:Q9NYZ3 GTSE1	4	GTSE1 [cytosol] (R-HSA-8852264) p-T513,T526-GTSE1 [cytosol] (R-HSA-8852308) p-S435-GTSE1 [nucleoplasm] (R-HSA-8852332) p-S435-GTSE1 [cytosol] (R-HSA-8852316)	0.527	2
UniProt:Q96CW1 AP2M1	6	AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [endolysosome membrane] (R-HSA-6784828) AP2M1 [lysosomal membrane] (R-HSA-196144) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.508	3

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