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OCRL [cytoplasmic vesicle membrane]
Stable Identifier
R-HSA-434214
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane
Synonyms
Inositol polyphosphate 5-phosphatase OCRL-1, OCRL_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
trans-Golgi Network Vesicle Budding (Homo sapiens)
Golgi Associated Vesicle Biogenesis (Homo sapiens)
trans-Golgi Network Derived Vesicle Uncoating (Homo sapiens)
Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex [cytoplasmic vesicle membrane] (Homo sapiens)
Golgi-associated Vesicle Cargo [cytoplasmic vesicle membrane] (Homo sapiens)
OCRL [cytoplasmic vesicle membrane] (Homo sapiens)
Golgi-associated Vesicle Cargo [cytoplasmic vesicle membrane] (Homo sapiens)
OCRL [cytoplasmic vesicle membrane] (Homo sapiens)
trans-Golgi Network Vesicle Scission (Homo sapiens)
Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex [cytoplasmic vesicle membrane] (Homo sapiens)
Golgi-associated Vesicle Cargo [cytoplasmic vesicle membrane] (Homo sapiens)
OCRL [cytoplasmic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01968 OCRL
Gene Names
OCRL, OCRL1
Chain
chain:1-901
Reference Genes
BioGPS Gene:4952 OCRL
COSMIC (genes):OCRL OCRL
CTD Gene:4952 OCRL
dbSNP Gene:4952 OCRL
ENSEMBL:ENSG00000122126 OCRL
HGNC:8108 OCRL
KEGG Gene (Homo sapiens):4952 OCRL
Monarch:4952 OCRL
NCBI Gene:4952 OCRL
OMIM:300535 OCRL
UCSC:Q01968 OCRL
Reference Transcript
RefSeq:NM_000276.3 OCRL
RefSeq:NM_001587.3 OCRL
Other Identifiers
0001400239
11717180_at
11717181_a_at
11755916_a_at
17106822
208316_s_at
34169_s_at
3990377
3990378
3990381
3990382
3990383
3990385
3990386
3990387
3990388
3990389
3990390
3990391
3990392
3990394
3990395
3990396
3990397
3990398
3990399
3990408
3990410
3990412
3990414
3990415
3990416
3990417
3990418
3990419
3990420
41227_at
4952
8169811
A_14_P121440
A_23_P170246
GO:0001701
GO:0001750
GO:0003674
GO:0004439
GO:0004445
GO:0005096
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005764
GO:0005768
GO:0005769
GO:0005773
GO:0005794
GO:0005795
GO:0005798
GO:0005802
GO:0005829
GO:0005886
GO:0005905
GO:0005929
GO:0005975
GO:0006629
GO:0006661
GO:0007165
GO:0008150
GO:0009056
GO:0009058
GO:0009790
GO:0010008
GO:0016020
GO:0016787
GO:0016791
GO:0019899
GO:0022607
GO:0030030
GO:0030136
GO:0030234
GO:0030670
GO:0031410
GO:0031901
GO:0042995
GO:0043087
GO:0043226
GO:0043547
GO:0043647
GO:0044281
GO:0046855
GO:0046856
GO:0048365
GO:0048856
GO:0051056
GO:0052658
GO:0052659
GO:0052745
GO:0060271
GO:0061024
ILMN_1760855
ILMN_2382121
PH_hs_0022390
TC0X000616.hg
U57627_at
g13249984_3p_a_at
g13325071_3p_a_at
Participant Of
hasCandidate
Golgi-associated Vesicle Cargo [cytoplasmic vesicle membrane]
Other forms of this molecule
OCRL [Golgi membrane]
OCRL [plasma membrane]
OCRL [cytosol]
Inferred To
Dd5P4 [cytoplasmic vesicle membrane] (Dictyostelium discoideum)
ocrl-1 [cytoplasmic vesicle membrane] (Caenorhabditis elegans)
OCRL [cytoplasmic vesicle membrane] (Canis familiaris)
OCRL [cytoplasmic vesicle membrane] (Gallus gallus)
OCRL [cytoplasmic vesicle membrane] (Sus scrofa)
OCRL [cytoplasmic vesicle membrane] (Xenopus tropicalis)
ocrl [cytoplasmic vesicle membrane] (Danio rerio)
Ocrl [cytoplasmic vesicle membrane] (Drosophila melanogaster)
Ocrl [cytoplasmic vesicle membrane] (Mus musculus)
Ocrl [cytoplasmic vesicle membrane] (Rattus norvegicus)
Cross References
RefSeq
NP_001578.2
,
NP_000267.2
OpenTargets
ENSG00000122126
IntEnz
3.1.3.56
HPA
ENSG00000122126-OCRL
GeneCards
Q01968
Ensembl
ENST00000371113
,
ENSG00000122126
,
ENSP00000349635
,
ENSP00000360154
,
ENST00000357121
PRO
Q01968
Orphanet
16585
HMDB Protein
HMDBP01569
PDB
2KIE
,
4CMN
,
2QV2
,
3QIS
,
3QBT
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P20340 RAB6A
8
RAB6A [Golgi membrane]
(R-HSA-1604442)
RAB6A [endoplasmic reticulum membrane]
(R-HSA-8849253)
RAB6A [secretory granule membrane]
(R-HSA-6804970)
RAB6A [plasma membrane]
(R-HSA-6804981)
RAB6A [cytosol]
(R-HSA-6810979)
GGC-RAB6A [cytosol]
(R-HSA-8874052)
GGC-RAB6A [trans-Golgi network membrane]
(R-HSA-8876079)
RAB6A [trans-Golgi network membrane]
(R-HSA-6810981)
0.835
13
UniProt:P20339 RAB5A
6
RAB5A [endosome membrane]
(R-HSA-452257)
RAB5A [cytosol]
(R-HSA-2201187)
RAB5A [early endosome membrane]
(R-HSA-2130175)
GGC-RAB5A [cytosol]
(R-HSA-8870432)
GGC-RAB5A [early endosome membrane]
(R-HSA-8875323)
GGC-RAB5A [clathrin-coated endocytic vesicle membrane]
(R-HSA-8871125)
0.799
11
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.556
3
UniProt:Q9UKG1 APPL1
1
APPL1 [endosome membrane]
(R-HSA-373630)
0.534
2
UniProt:Q9NYZ3 GTSE1
4
GTSE1 [cytosol]
(R-HSA-8852264)
p-T513,T526-GTSE1 [cytosol]
(R-HSA-8852308)
p-S435-GTSE1 [nucleoplasm]
(R-HSA-8852332)
p-S435-GTSE1 [cytosol]
(R-HSA-8852316)
0.527
2
UniProt:Q96CW1 AP2M1
6
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.508
3
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