Reactome | GAK [Golgi membrane]

GAK [Golgi membrane]

Stable Identifier

R-HSA-434340

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Cyclin G-associated kinase, GAK_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - trans-Golgi Network Vesicle Budding (Homo sapiens)
    - Golgi Associated Vesicle Biogenesis (Homo sapiens)
      - Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Homo sapiens)
        
        Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
        
        Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
        
        GAK [Golgi membrane] (Homo sapiens)
        
        Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
        
        GAK [Golgi membrane] (Homo sapiens)
      - trans-Golgi Network Coat Assembly (Homo sapiens)
        
        Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
        
        Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
        
        GAK [Golgi membrane] (Homo sapiens)
        
        Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Homo sapiens)
        
        Cargo:AP-1:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
        
        Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
        
        GAK [Golgi membrane] (Homo sapiens)
      - trans-Golgi Network Vesicle Scission (Homo sapiens)
        
        Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Homo sapiens)
        
        Cargo:AP-1:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
        
        Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
        
        GAK [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14976 GAK

Gene Names

GAK, DNAJC26

Chain

initiator methionine:, chain:2-1311

Reference Genes

BioGPS Gene:2580 GAK

COSMIC (genes):GAK GAK

CTD Gene:2580 GAK

dbSNP Gene:2580 GAK

ENSEMBL:ENSG00000178950 GAK

ENSEMBL_homo_sapiens_GENE:ENSG00000178950.18 GAK

HGNC:4113 GAK

KEGG Gene (Homo sapiens):2580 GAK

Monarch:2580 GAK

NCBI Gene:2580 GAK

OMIM:602052 GAK

UCSC:O14976 GAK

Reference Transcript

Other Identifiers

11721027_a_at

11754278_x_at

16973375

202281_PM_at

202281_at

2580

2756674

2756675

2756676

2756677

2756678

2756679

2756682

2756684

2756685

2756693

2756694

2756696

2756697

2756699

2756700

2756701

2756702

2756705

2756711

2756713

2756714

2756724

2756725

2756726

2756728

2756731

2756737

2756739

2756743

2756746

2756747

2756757

2756759

2756765

2756766

2756767

2756770

2756771

2756776

2756777

40225_PM_at

40225_at

8098789

A_23_P155700

A_24_P397150

GE57429

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005737

GO:0005794

GO:0005829

GO:0005925

GO:0006457

GO:0006468

GO:0006898

GO:0007029

GO:0007030

GO:0007049

GO:0010977

GO:0016020

GO:0016191

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0030136

GO:0030154

GO:0030276

GO:0030332

GO:0031410

GO:0031982

GO:0034067

GO:0036211

GO:0043226

GO:0043231

GO:0046907

GO:0048268

GO:0048471

GO:0048856

GO:0051085

GO:0051087

GO:0065003

GO:0070161

GO:0072318

GO:0072583

GO:0072659

GO:0090160

GO:0098793

GO:0106310

GO:0140096

GO:1905443

HMNXSV003035454

HMNXSV003048962

ILMN_1813775

PH_hs_0009213

TC04000957.hg

g4885250_3p_s_at

Participates

as a candidate of

Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)

Other forms of this molecule

GAK [cytoplasmic vesicle membrane]

GAK [cytosol]

Inferred To

Gak [Golgi membrane] (Rattus norvegicus)

gak [Golgi membrane] (Xenopus tropicalis)

dnj-25 [Golgi membrane] (Caenorhabditis elegans)

GAK [Golgi membrane] (Bos taurus)

GAK [Golgi membrane] (Canis familiaris)

GAK [Golgi membrane] (Dictyostelium discoideum)

GAK [Golgi membrane] (Mus musculus)

GAK [Golgi membrane] (Sus scrofa)

SWA2 [Golgi membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001305063.1, NP_005246.2

ZINC - World Drugs

GAK_HUMAN

Guide to Pharmacology - Targets

2027

OpenTargets

ENSG00000178950

ZINC - FDA approved

GAK_HUMAN

ZINC - Substances

GAK_HUMAN

ZINC target

O14976

ZINC - Biogenic

GAK_HUMAN

PRO

O14976

PDB

4C59, 4C57, 4O38, 4C58, 5Y80, 4Y8D, 5Y7Z

ZINC - Investigational

GAK_HUMAN

HPA

ENSG00000178950-GAK

GeneCards

O14976

Ensembl

ENSG00000178950, ENSP00000421361, ENSP00000314499, ENST00000314167, ENST00000511163

Pharos - Targets

O14976

ZINC - Predictions - Purchasable

GAK_HUMAN

HMDB Protein

HMDBP09468

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.793	11
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.763	9
UniProt:Q96FJ0 STAMBPL1	1	STAMBPL1 [cytosol] (R-HSA-6783264)	0.643	3
UniProt:Q9P296 C5AR2	1	C5AR2 [plasma membrane] (R-HSA-964798)	0.527	2
UniProt:O95630 STAMBP	1	STAMBP [cytosol] (R-HSA-5693063)	0.527	2
UniProt:Q9NSE4 IARS2	1	IARS2 [mitochondrial matrix] (R-HSA-379571)	0.527	2
UniProt:Q9NQ11 ATP13A2	1	ATP13A2 [lysosomal lumen] (R-HSA-939762)	0.508	2