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TGOLN2 [Golgi membrane]
Stable Identifier
R-HSA-434342
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
Trans-Golgi network integral membrane protein 2, TGON2_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
trans-Golgi Network Vesicle Budding (Homo sapiens)
Golgi Associated Vesicle Biogenesis (Homo sapiens)
Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Homo sapiens)
Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
TGOLN2 [Golgi membrane] (Homo sapiens)
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
TGOLN2 [Golgi membrane] (Homo sapiens)
trans-Golgi Network Coat Assembly (Homo sapiens)
Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
TGOLN2 [Golgi membrane] (Homo sapiens)
Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Homo sapiens)
Cargo:AP-1:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
TGOLN2 [Golgi membrane] (Homo sapiens)
trans-Golgi Network Vesicle Scission (Homo sapiens)
Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Homo sapiens)
Cargo:AP-1:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
TGOLN2 [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43493 TGOLN2
Gene Names
TGOLN2, TGN46, TGN51
Chain
signal peptide:1-21, chain:22-437
Reference Genes
BioGPS Gene:10618 TGOLN2
COSMIC (genes):TGOLN2 TGOLN2
CTD Gene:10618 TGOLN2
dbSNP Gene:10618 TGOLN2
ENSEMBL:ENSG00000152291 TGOLN2
HGNC:15450 TGOLN2
KEGG Gene (Homo sapiens):10618 TGOLN2
Monarch:10618 TGOLN2
NCBI Gene:10618 TGOLN2
OMIM:603062 TGOLN2
UCSC:O43493 TGOLN2
Reference Transcript
RefSeq:NM_001206841.1 TGOLN2
RefSeq:NM_006464.3 TGOLN2
RefSeq:NM_001206840.1 TGOLN2
RefSeq:NM_001206844.1 TGOLN2
Other Identifiers
0002260162
10618
11716901_s_at
11716902_a_at
11716903_a_at
11716904_s_at
11755687_x_at
1566473_3p_a_at
1566473_a_at
16899619
203833_s_at
203834_s_at
212040_3p_at
212040_at
212043_at
2491521
2562200
2562201
2562202
2562203
2562204
2562205
2562209
2562210
2562211
2562212
2562213
2562214
2562215
2562216
2562217
2562218
2562220
2562221
2562222
2562224
2562226
2562228
2562230
31827_s_at
31828_r_at
31829_r_at
38993_r_at
8053388
A_23_P209933
A_24_P413988
GE81643
GE86506
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005783
GO:0005788
GO:0005794
GO:0005802
GO:0005886
GO:0006464
GO:0008150
GO:0016020
GO:0016021
GO:0030133
GO:0030140
GO:0030665
GO:0031410
GO:0043226
GO:0043687
GO:0044267
GO:0061024
Hs.110771.0.S1_3p_x_at
Hs.110771.0.S2_3p_at
Hs.14894.0.S1_3p_a_at
Hs.14894.0.S1_3p_s_at
ILMN_1651735
PH_hs_0001402
PH_hs_0040170
TC02002035.hg
X94333_at
g5454115_3p_a_at
Participant Of
hasCandidate
Golgi-associated Vesicle Destined Cargo [Golgi membrane]
Other forms of this molecule
TGOLN2 [endoplasmic reticulum lumen]
p-TGOLN2 [endoplasmic reticulum lumen]
TGOLN2 [transport vesicle]
TGOLN2 [trans-Golgi network membrane]
TGOLN2 [cytoplasmic vesicle membrane]
TGOLN2 [plasma membrane]
TGOLN2 [clathrin-coated endocytic vesicle membrane]
Inferred To
Tgoln1 [Golgi membrane] (Mus musculus)
TGOLN2 [Golgi membrane] (Canis familiaris)
TGOLN2 [Golgi membrane] (Gallus gallus)
Ttgn1 [Golgi membrane] (Rattus norvegicus)
Cross References
RefSeq
NP_001193773.1
,
NP_001193770.1
,
NP_001193769.1
,
NP_006455.2
OpenTargets
ENSG00000152291
HPA
ENSG00000152291-TGOLN2
GeneCards
O43493
Ensembl
ENST00000398263
,
ENST00000377386
,
ENSP00000366603
,
ENSP00000387035
,
ENST00000444342
,
ENST00000409015
,
ENSG00000152291
,
ENSP00000391190
,
ENSP00000381312
PRO
O43493
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H3P7 ACBD3
1
ACBD3 [Golgi membrane]
(R-HSA-8874981)
0.577
5
UniProt:P27986 PIK3R1
15
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
0.564
2
UniProt:Q9NZ52 GGA3
3
GGA3 [recycling endosome membrane]
(R-HSA-8875655)
GGA3 [endosome membrane]
(R-HSA-5692936)
GGA3 [early endosome membrane]
(R-HSA-8854137)
0.491
3
UniProt:Q14677 CLINT1
1
CLINT1 [cytosol]
(R-HSA-429811)
0.462
4
UniProt:Q07065 CKAP4
7
PALM-C100-CKAP4 [plasma membrane]
(R-HSA-5686280)
PALM-C100-CKAP4 [lamellar body]
(R-HSA-5686285)
CKAP4 [specific granule membrane]
(R-HSA-6799552)
CKAP4 [plasma membrane]
(R-HSA-5686306)
CKAP4 [azurophil granule membrane]
(R-HSA-6799559)
p-CKAP4 [endoplasmic reticulum lumen]
(R-HSA-8956926)
CKAP4 [endoplasmic reticulum lumen]
(R-HSA-8956737)
0.462
2
UniProt:Q9H2J7 SLC6A15
1
SLC6A15 [plasma membrane]
(R-HSA-352060)
0.462
4
UniProt:Q04721 NOTCH2
18
NOTCH2(1666-1696) [plasma membrane]
(R-HSA-157628)
NOTCH2(1582-1665) [extracellular region]
(R-HSA-157652)
NEXT2 [plasma membrane]
(R-HSA-157225)
NICD2 [cytosol]
(R-HSA-157642)
NICD2 [nucleoplasm]
(R-HSA-157942)
Glc,GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane]
(R-HSA-1911428)
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane]
(R-HSA-1911417)
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane]
(R-HSA-1911505)
FRINGE-modified NOTCH2 Extracellular Fragment (NECD2) [plasma membrane]
(R-HSA-1911518)
FRINGE-modified NOTCH2 extracellular fragment (NECD2) [Golgi membrane]
(R-HSA-1911520)
Pre-NOTCH2 [endoplasmic reticulum membrane]
(R-HSA-157025)
18xFucT-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane]
(R-HSA-1467363)
18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane]
(R-HSA-1467379)
18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [Golgi membrane]
(R-HSA-1472874)
NOTCH2(1582-2471) [plasma membrane]
(R-HSA-157228)
18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [extracellular region]
(R-HSA-1983678)
NOTCH2(1582-2471) [Golgi membrane]
(R-HSA-157017)
18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [Golgi membrane]
(R-HSA-1983676)
0.462
2
UniProt:Q14739 LBR
2
LBR [nuclear envelope]
(R-HSA-194637)
p-S71,S86-LBR [nuclear envelope]
(R-HSA-9624811)
0.462
2
UniProt:Q9NZC7 WWOX
1
WWOX [cytosol]
(R-HSA-1253335)
0.462
2
UniProt:P35613 BSG
2
BSG [Golgi membrane]
(R-HSA-204478)
BSG [plasma membrane]
(R-HSA-197673)
0.462
2
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