ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell

Stable Identifier
R-HSA-434382
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ACSL3 and ACSL4 found on the mitochondria of pancreatic beta cells ligate coenzyme A (Co-A) to fatty acids such as palmitate (Ansari et al. 2017) prior to transport into mitochondria by the carnitine system and beta oxidation in the mitochondrial matrix yielding ATP.

Literature References
PubMed ID Title Journal Year
28193492 Characterization of Acyl-CoA synthetase isoforms in pancreatic beta cells: Gene silencing shows participation of ACSL3 and ACSL4 in insulin secretion

Ansari, IH, Longacre, MJ, Stoker, SW, Kendrick, MA, O'Neill, LM, Zitur, LJ, Fernandez, LA, Ntambi, JM, MacDonald, MJ

Arch. Biochem. Biophys. 2017
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
palmitoyl-CoA ligase activity of ACSL3,4 [mitochondrial outer membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created