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KLF4 [nucleoplasm]
Stable Identifier
R-HSA-434463
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Krueppel-like factor 4, KLF4_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Transcriptional regulation of pluripotent stem cells (Homo sapiens)
Expression of NANOG (Homo sapiens)
KLF4 [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene [nucleoplasm] (Homo sapiens)
KLF4 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter (Homo sapiens)
KLF4 [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene [nucleoplasm] (Homo sapiens)
KLF4 [nucleoplasm] (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of CEBPB in adipogenesis (Homo sapiens)
KLF4 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of cell cycle genes (Homo sapiens)
KLF4 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)
KLF4 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Synthesis, secretion, and deacylation of Ghrelin (Homo sapiens)
Expression of Preproghrelin (Homo sapiens)
KLF4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43474 KLF4
Gene Names
KLF4, EZF, GKLF
Chain
chain:1-513
Reference Genes
BioGPS Gene:9314 KLF4
COSMIC (genes):KLF4 KLF4
CTD Gene:9314 KLF4
dbSNP Gene:9314 KLF4
ENSEMBL:ENSG00000136826 KLF4
HGNC:6348 KLF4
KEGG Gene (Homo sapiens):9314 KLF4
Monarch:9314 KLF4
NCBI Gene:9314 KLF4
OMIM:602253 KLF4
UCSC:O43474 KLF4
Reference Transcript
RefSeq:NM_004235.5 KLF4
RefSeq:NM_001314052.1 KLF4
Other Identifiers
0000520139
11719633_a_at
11719634_a_at
17096827
220266_s_at
221841_s_at
3219225
3219226
3219227
3219228
3219229
3219230
3219233
3219235
3219240
3219242
3219243
36214_at
48587_at
8163002
9314
A_23_P32233
GE86000
GE86001
GO:0000122
GO:0000228
GO:0000278
GO:0000785
GO:0000790
GO:0000976
GO:0000978
GO:0000981
GO:0000987
GO:0001010
GO:0001085
GO:0001221
GO:0001228
GO:0002376
GO:0003674
GO:0003676
GO:0003677
GO:0003690
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005719
GO:0005737
GO:0006259
GO:0006351
GO:0006357
GO:0006464
GO:0006629
GO:0006950
GO:0007049
GO:0007155
GO:0007165
GO:0007267
GO:0007500
GO:0008013
GO:0008134
GO:0008150
GO:0008219
GO:0008270
GO:0008283
GO:0008285
GO:0009058
GO:0009790
GO:0009913
GO:0010033
GO:0010628
GO:0010629
GO:0014067
GO:0014740
GO:0016525
GO:0019827
GO:0019899
GO:0030154
GO:0030234
GO:0030336
GO:0031077
GO:0032088
GO:0032270
GO:0032526
GO:0032717
GO:0032991
GO:0034115
GO:0034641
GO:0035014
GO:0035019
GO:0035166
GO:0040011
GO:0042127
GO:0042826
GO:0043154
GO:0043167
GO:0043226
GO:0043433
GO:0043551
GO:0043565
GO:0045429
GO:0045444
GO:0045595
GO:0045892
GO:0045893
GO:0045944
GO:0046872
GO:0046985
GO:0048646
GO:0048662
GO:0048679
GO:0048730
GO:0048856
GO:0048870
GO:0050728
GO:0051247
GO:0051898
GO:0051973
GO:0060070
GO:0060761
GO:0070301
GO:0070373
GO:0071300
GO:0071363
GO:0071407
GO:0071409
GO:0071499
GO:0090051
GO:0120222
GO:1901653
GO:1902895
GO:1903672
GO:1904798
GO:1904998
GO:1990830
GO:1990837
GO:1990841
GO:2000134
GO:2000342
ILMN_1779857
ILMN_2137789
PH_hs_0032978
TC09001447.hg
U70663_at
g4758321_3p_a_at
Participant Of
output
KLF4 gene expression is stimulated by FOXO1,FOXO3
input
POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter
hasComponent
POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene [nucleoplasm]
This entity regulates
Positively
Expression of Preproghrelin
Expression of CEBPB in adipogenesis
Inferred To
cbt [nucleoplasm] (Drosophila melanogaster)
sptf-1 [nucleoplasm] (Caenorhabditis elegans)
klf2b [nucleoplasm] (Danio rerio)
klf4 [nucleoplasm] (Xenopus tropicalis)
dar1 [nucleoplasm] (Drosophila melanogaster)
Klf15 [nucleoplasm] (Drosophila melanogaster)
Klf4 [nucleoplasm] (Mus musculus)
Klf4 [nucleoplasm] (Rattus norvegicus)
CG9895 [nucleoplasm] (Drosophila melanogaster)
klf-1 [nucleoplasm] (Caenorhabditis elegans)
KLF4 [nucleoplasm] (Bos taurus)
KLF4 [nucleoplasm] (Canis familiaris)
KLF4 [nucleoplasm] (Sus scrofa)
klf-2 [nucleoplasm] (Caenorhabditis elegans)
luna [nucleoplasm] (Drosophila melanogaster)
Homologues of KLF4 [nucleoplasm] (Caenorhabditis elegans)
Homologues of KLF4 [nucleoplasm] (Drosophila melanogaster)
klf-3 [nucleoplasm] (Caenorhabditis elegans)
Cross References
RefSeq
NP_001300981.1
,
NP_004226.3
OpenTargets
ENSG00000136826
GeneCards
O43474
HPA
ENSG00000136826-KLF4
Ensembl
ENST00000374672
,
ENSP00000363804
,
ENSG00000136826
PRO
O43474
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75031 HSF2B
0.556
3
UniProt:A0A024R8L2 A0A024R8L2
0.556
3
UniProt:P13807 GYS1
3
GYS1 [cytosol]
(R-HSA-71565)
GYS1 R462* [cytosol]
(R-HSA-3828056)
p-S-GYS1 [cytosol]
(R-HSA-71570)
0.556
5
UniProt:Q08117-2 TLE5
0.556
3
UniProt:O14964 HGS
2
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
HGS [cytosol]
(R-HSA-182954)
0.556
3
UniProt:Q92997 DVL3
4
p-DVL3 [cytosol]
(R-HSA-201680)
pp-DVL3 [cytosol]
(R-HSA-3772400)
DVL3 [cytosol]
(R-HSA-201678)
ub-DVL3 [cytosol]
(R-HSA-4652688)
0.556
3
UniProt:P55771 PAX9
0.556
3
IntAct:EBI-11177518 CD14
0.544
2
IntAct:EBI-11177705 CD14
0.544
2
UniProt:Q13363 CTBP1
3
CTBP1 [nucleoplasm]
(R-HSA-212372)
SUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
SUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
0.524
4
UniProt:O95983 MBD3
1
MBD3 [nucleoplasm]
(R-HSA-4657010)
0.499
3
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