PIP2 binds inhibiting VAV

Stable Identifier
R-HSA-434633
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Vav interacts directly with PIP2 and PIP3, with a fivefold selectivity for PIP3 over PIP2. PIP3 gives a twofold stimulation of Vav1 GEF activity while PIP2 leads to 90% inhibition. Binding probably occurs through the PH domain, known to bind phosphoinositides.
Literature References
PubMed ID Title Journal Year
9438848 Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

White, MA, Falck, JR, Mosteller, RD, Xia, Y, Han, J, Shu, X, Das, B, Luby-Phelps, K, Krishna, UM, Broek, D

Science 1998
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