STIM1 activation of CRAC

Stable Identifier
R-HSA-434700
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Sustained calcium signalling in lymphocytes and platelets requires the uptake of extracellular calcium when intracellular stores are depleted. The process whereby intracellular calcium depletion stimulates calcium uptake is often referred to as Store-operated calcium entry (SOCE). Store depletion is sensed by stromal interaction molecule 1 (STIM1), which then translocates to the plasma membrane and associates with 2 dimers of Orai to form a calcium-release activated calcium (CRAC) channel.

Literature References
PubMed ID Title Journal Year
18187424 Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation

Muik, M, Frischauf, I, Derler, I, Fahrner, M, Bergsmann, J, Eder, P, Schindl, R, Hesch, C, Polzinger, B, Fritsch, R, Kahr, H, Madl, J, Gruber, H, Groschner, K, Romanin, C

J Biol Chem 2008
17452328 Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels

DeHaven, WI, Smyth, JT, Boyles, RR, Putney, JW

J. Biol. Chem. 2007
19249086 STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1

Park, CY, Hoover, PJ, Mullins, FM, Bachhawat, P, Covington, ED, Raunser, S, Walz, T, Garcia, KC, Dolmetsch, RE, Lewis, RS

Cell 2009
18596693 Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

Luik, RM, Wang, B, Prakriya, M, Wu, MM, Lewis, RS

Nature 2008
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