ZnT5 transports zinc into secretory granules in pancreatic beta cells

Stable Identifier
R-HSA-437085
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The human gene SLC30A5 encodes the zinc transporter ZnT5. This protein is widely expressed but is most abundant in pancreatic beta cells (Kambe T et al, 2002). In these cells, ZnT5 mediates the transport of zinc into secretory granules that contain insulin.

Literature References
PubMed ID Title Journal Year
11904301 Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells

Kambe, T, Narita, H, Yamaguchi-Iwai, Y, Hirose, J, Amano, T, Sugiura, N, Sasaki, R, Mori, K, Iwanaga, T, Nagao, M

J Biol Chem 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
zinc ion transmembrane transporter activity of SLC30A5 [secretory granule membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed