Reactome | SLC30A8 [secretory granule membrane]

SLC30A8 [secretory granule membrane]

Stable Identifier

R-HSA-437106

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule membrane

Synonyms

ZnT8, Zinc transporter 8, ZNT8_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q8IWU4 SLC30A8

Gene Names

SLC30A8, ZNT8

Chain

chain:1-369

Reference Genes

BioGPS Gene:169026 SLC30A8

COSMIC (genes):SLC30A8 SLC30A8

CTD Gene:169026 SLC30A8

dbSNP Gene:169026 SLC30A8

ENSEMBL:ENSG00000164756 SLC30A8

ENSEMBL_homo_sapiens_GENE:ENSG00000164756.13 SLC30A8

HGNC:20303 SLC30A8

KEGG Gene (Homo sapiens):169026 SLC30A8

Monarch:169026 SLC30A8

NCBI Gene:169026 SLC30A8

OMIM:611145 SLC30A8

UCSC:Q8IWU4 SLC30A8

Reference Transcript

Other Identifiers

11725814_a_at

11725815_a_at

11748812_s_at

11752953_a_at

1552985_PM_at

1552985_at

169026

17072059

239983_PM_at

239983_at

3112585

3112586

3112587

3112592

3112608

3112609

3112610

3112611

3112612

3112619

3112620

3112621

3112624

3112625

3112626

3112627

3112628

3112629

3112630

3112631

65344_at

8148003

86126_at

A_14_P138620

A_23_P362798

A_33_P3283813

GE549983

GE88788

GO:0000139

GO:0002376

GO:0005215

GO:0005385

GO:0005515

GO:0005794

GO:0005886

GO:0006811

GO:0006812

GO:0006829

GO:0006882

GO:0008270

GO:0008324

GO:0009749

GO:0010043

GO:0015297

GO:0016020

GO:0016192

GO:0023052

GO:0030070

GO:0030073

GO:0030141

GO:0030658

GO:0030667

GO:0031410

GO:0032024

GO:0034341

GO:0042803

GO:0043226

GO:0043231

GO:0046872

GO:0051604

GO:0055065

GO:0055085

GO:0060627

GO:0062111

GO:0070555

GO:0071577

GO:0071578

GO:0098542

GO:0140826

HMNXSV003003107

HMNXSV003015802

Hs.170042.0.A1_3p_at

Hs2.179082.1.S1_3p_at

ILMN_1774869

PH_hs_0010622

TC08000685.hg

Other forms of this molecule

SLC30A8 [Golgi membrane]

Inferred To

SLC30A8 [secretory granule membrane] (Bos taurus)

SLC30A8 [secretory granule membrane] (Canis familiaris)

SLC30A8 [secretory granule membrane] (Dictyostelium discoideum)

SLC30A8 [secretory granule membrane] (Gallus gallus)

SLC30A8 [secretory granule membrane] (Mus musculus)

SLC30A8 [secretory granule membrane] (Plasmodium falciparum)

SLC30A8 [secretory granule membrane] (Rattus norvegicus)

SLC30A8 [secretory granule membrane] (Sus scrofa)

SLC30A8 [secretory granule membrane] (Xenopus tropicalis)

ZnT41F [secretory granule membrane] (Drosophila melanogaster)

cdf-2 [secretory granule membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001166282.1, NP_001166285.1, NP_001166284.1, NP_001166286.1, NP_776250.2

Guide to Pharmacology - Targets

1128

OpenTargets

ENSG00000164756

HPA

ENSG00000164756-SLC30A8

GeneCards

Q8IWU4

Ensembl

ENSP00000428545, ENSP00000431069, ENST00000521243, ENST00000519688, ENST00000456015, ENSP00000407505, ENSP00000415011, ENSG00000164756, ENST00000427715

PRO

Q8IWU4

Pharos - Targets

Q8IWU4

HMDB Protein

HMDBP12042

PDB

6XPE, 6XPD, 6XPF

Interactors (79)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.805	9
UniProt:Q8WZ55 BSND	1	BSND [plasma membrane] (R-HSA-2854996)	0.556	3
UniProt:O60636 TSN2			0.556	3
UniProt:Q9NPE6 SPAG4			0.556	3
UniProt:P23763-3 VAMP1			0.556	3
UniProt:Q8NC24 RELL2			0.556	3
UniProt:Q99675 CGRF1			0.556	3
UniProt:Q96KR6 F210B			0.556	3
UniProt:P15941-11 MUC1			0.556	3
UniProt:Q99640-2 PKMYT1			0.556	3
UniProt:Q9BSR8 YIPF4			0.556	3
UniProt:Q8IV31 TM139			0.556	3
UniProt:P30519 HMOX2	3	HMOX2 [plasma membrane] (R-HSA-6799676) HMOX2 [specific granule membrane] (R-HSA-6799628) HMOX2 [endoplasmic reticulum membrane] (R-HSA-189391)	0.556	3
UniProt:Q9P0T7 TMEM9			0.556	3
UniProt:Q9BUN8 DERL1	1	DERL1 [endoplasmic reticulum membrane] (R-HSA-6781898)	0.556	3
IntAct:EBI-22589183 CCSB ORF ID			0.556	3
UniProt:Q8WV19 SFT2A			0.556	3
UniProt:Q96MG2 JSPR1			0.556	3
IntAct:EBI-23641393 CCSB ORF ID			0.556	3
UniProt:Q96EC8 YIPF6	2	YIPF6 [Golgi membrane] (R-HSA-434346) YIPF6 [cytoplasmic vesicle membrane] (R-HSA-434199)	0.556	3
UniProt:Q9NVJ2 ARL8B			0.556	3
UniProt:Q99726 SLC30A3	1	SLC30A3 [synaptic vesicle membrane] (R-HSA-437087)	0.556	3
UniProt:P63027 VAMP2	20	VAMP2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869129) VAMP2 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-379363) VAMP2 [plasma membrane] (R-HSA-210516) VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917738) VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210365) VAMP2 [synaptic vesicle membrane] (R-HSA-181517) VAMP2(59-116) [synaptic vesicle membrane] (R-HSA-5250891) VAMP2(2-58) [cytosol] (R-HSA-194815) VAMP2(2-76) [cytosol] (R-HSA-194802) VAMP2(77-116) [synaptic vesicle membrane] (R-HSA-5228355) VAMP2(60-116) [synaptic vesicle membrane] (R-HSA-5250615) VAMP2(2-59) [cytosol] (R-HSA-194797) VAMP2(82-116) [synaptic vesicle membrane] (R-HSA-5250961) VAMP2(2-81) [cytosol] (R-HSA-5250970) VAMP2 [secretory granule membrane] (R-HSA-376363) VAMP2 [cytosol] (R-HSA-9609882) VAMP2 [endoplasmic reticulum membrane] (R-HSA-9609886) VAMP2 [cytoplasmic vesicle membrane] (R-HSA-1449630) VAMP2 [lysosomal membrane] (R-HSA-432703) VAMP2 [Golgi membrane] (R-HSA-375425)	0.556	3
UniProt:Q9NY72 SCN3B	1	SCN3B [plasma membrane] (R-HSA-197921)	0.556	3
UniProt:Q4KMG9 TM52B			0.556	3
UniProt:Q9NP94 SLC39A2	1	SLC39A2 [plasma membrane] (R-HSA-442395)	0.556	3
UniProt:Q9H6H4 REEP4			0.556	3
UniProt:Q5JX71 F209A			0.556	3
UniProt:P56747 CLDN6	2	CLDN6 [plasma membrane] (R-HSA-419992) CLDN6 [cell junction] (R-HSA-421250)	0.556	3
UniProt:P26678 PLN	2	p-S16-PLN [sarcoplasmic reticulum membrane] (R-HSA-5578813) PLN [sarcoplasmic reticulum membrane] (R-HSA-5490319)	0.556	3
UniProt:Q9GZR5 ELOVL4	1	ELOVL4 [endoplasmic reticulum membrane] (R-HSA-548705)	0.556	3
UniProt:Q8N9I0 SYT2	3	SYT2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869116) SYT2 [plasma membrane] (R-HSA-168795) SYT2 [synaptic vesicle membrane] (R-HSA-194786)	0.556	3
UniProt:Q16617 NKG7			0.556	3
UniProt:Q5T4F4 ZFY27			0.556	3
UniProt:Q96FZ5 CKLF7			0.556	3
UniProt:Q96HE8 TMM80			0.556	3
UniProt:P13236 CCL4	1	CCL4(24-92) [extracellular region] (R-HSA-443976)	0.556	3
IntAct:EBI-22326698 CCSB ORF ID			0.556	3
UniProt:O95197-3 RTN3			0.556	3
UniProt:P16157-17 ANK1			0.556	3
UniProt:Q9HD20-3 ATP13A1			0.556	3
UniProt:Q8TBE3 FNDC9			0.556	3
UniProt:Q8WY91 THAP4			0.556	3
UniProt:O95562 SFT2B			0.556	3
UniProt:Q9NUU6 OTULL			0.556	3
UniProt:Q8N2H4 SYS1	1	SYS1 [trans-Golgi network membrane] (R-HSA-6813921)	0.556	3
UniProt:Q9NP66 HM20A			0.556	3
UniProt:O95807 TM50A			0.556	3
UniProt:Q8WWF3 SSMM1			0.556	3
UniProt:Q9NUH8 TM14B			0.556	3
UniProt:Q96HR9-2 REEP6			0.556	3
UniProt:P60508 SYCY2			0.556	3
UniProt:O15529 GPR42			0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:Q9Y6D0 SELK			0.556	3
UniProt:Q9BTX3 TM208			0.556	3
UniProt:Q96GQ5 RUSF1			0.556	3
UniProt:Q96Q45-2 TMEM237			0.556	3
UniProt:Q7Z7G2 CPLX4			0.556	3
UniProt:Q96TC7 RMD3			0.556	3
UniProt:Q9C0I4 THSD7B	3	THSD7B [endoplasmic reticulum lumen] (R-HSA-5173101) glc-fuc-THSD7B [endoplasmic reticulum lumen] (R-HSA-5172957) O-fuc-THSD7B [endoplasmic reticulum lumen] (R-HSA-5173124)	0.556	3
UniProt:Q9P0S3 ORMDL1	1	ORMDL1 [endoplasmic reticulum membrane] (R-HSA-8865584)	0.556	3
UniProt:Q14416 GRM2	1	GRM2 [plasma membrane] (R-HSA-420468)	0.556	3
UniProt:Q96IV6 FXDC2			0.556	3
UniProt:Q9NR31 SAR1A			0.556	3
UniProt:P43378 PTPN9	1	PTPN9 [nucleoplasm] (R-HSA-9008907)	0.556	3
UniProt:Q9BXK5 B2L13			0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:P54219-3 P542193			0.556	3
UniProt:Q13323 BIK			0.556	3
UniProt:Q8NBQ5 HSD17B11	1	HSD17B11 [cytosol] (R-HSA-5693370)	0.556	3
UniProt:P17152 TMEM11	1	TMEM11 [mitochondrial inner membrane] (R-HSA-8949578)	0.556	3
UniProt:P12004 PCNA	5	monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) PCNA [nucleoplasm] (R-HSA-68439)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:O15173 PGRMC2	4	PGRMC2 [nuclear envelope] (R-HSA-9707674) PGRMC2 [nucleoplasm] (R-HSA-9707859) PGRMC2 [endoplasmic reticulum membrane] (R-HSA-9714349) PGRMC2 [endosome membrane] (R-HSA-9715090)	0.556	3
UniProt:O60883 GPR37L1	1	GPR37L1 [plasma membrane] (R-HSA-5336178)	0.556	3
UniProt:A8MZ59 LEUTX	1	LEUTX [nucleoplasm] (R-HSA-9817277)	0.556	3
UniProt:Q8TCZ2 CD99L2	1	CD99L2 [plasma membrane] (R-HSA-8867207)	0.556	3
UniProt:P08563-PRO_0000041304			0.524	2

Cite Us!