Reactome | ZnT8 transports zinc into the Golgi apparatus

ZnT8 transports zinc into the Golgi apparatus

Stable Identifier

R-HSA-437139

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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Transport of small molecules (Homo sapiens)

- SLC-mediated transmembrane transport (Homo sapiens)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
    - Metal ion SLC transporters (Homo sapiens)
      - Zinc transporters (Homo sapiens)
        
        Zinc efflux and compartmentalization by the SLC30 family (Homo sapiens)
        
        ZnT8 transports zinc into the Golgi apparatus (Homo sapiens)

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ZnT8 transports zinc into the Golgi apparatus

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Dimeric ZnT8/SLC30A8 mediates the transport of cytosolic Zn2+ into the lumen of the Golgi apparatus. The protein is expressed in human pancreatic beta cells and localizes with the Golgi apparatus and insulin-containing secretory granules (Bosco et al. 2010; Chimienti et al. 2006; Kambe et al. 2021).

Literature References

PubMed ID	Title	Journal	Year
21713314	Zinc and zinc transporter regulation in pancreatic islets and the potential role of zinc in islet transplantation Zalewski, PD, Coates, PT, Lang, CJ, Mohanasundaram, DM, Drogemuller, CJ, Bosco, MD	Rev Diabet Stud	2010
33485965	Zinc transporters and their functional integration in mammalian cells Kambe, T, Fu, D, Taylor, KM	J Biol Chem	2021
16984975	In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion Schuit, F, Vandewalle, B, Seve, M, Favier, A, Devergnas, S, Chimienti, F, Grunwald, D, Garcia-Cuenca, R, Van Lommel, L, Kerr-Conte, J, Pattou, F	J Cell Sci	2006