Reactome: A Curated Pathway Database

L1-FGFR cis-heterodimerization

Stable Identifier
R-HSA-437230
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

L1-L1 trans-homodimers interact with the fibroblast growth factor receptor (FGFR). The CAM homology domain (CHD) in the FGFR, which resides between Ig like domains 1 and 2, interacts with the putative FGFR-CHD binding motif in the Fn3 module 4 of L1. This interaction leads to activation of the tyrosine kinase domain of the FGFR and subsequent activation of PLCgamma. PLCgamma then hydrolyses PIP2 to generate IP3 and DAG which finally leads to an increase in localized Ca+2 influx and activation of Ca+2/Calmodulin kinase II.

Literature References
Participants
Participant Of
Orthologous Events