SLC31A1 transports Cu2+ from extracellular region to cytosol

Stable Identifier
R-HSA-437300
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Cellular copper transport is mediated by human copper transporter 1 hCTR1
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Copper (Cu2+) is essential for many important biological processes such as mitochondrial oxidative phosphorylation, detoxification of free radicals, iron metabolism and neurotransmiter synthesis. Too much influx results in cell poisoning. In humans, there are two member of the SLC31 gene family that are implicated in copper transport. The human gene SLC31A1 encodes human copper transporter 1, hCTR1 and is ubiquitiously expressed, with highest levels seen in the liver.. It was first identified by functional complementation in ctr1-deficient yeast (Zhou B and Gitschier J, 1997). hCTR1 exists as a homotrimer at the plasma membrane of cells (De Feo CJ et al, 2007) and is responsible for high-affinity copper uptake (Lee J et al, 2002). The second gene product, hCTR2, has not be characterized yet.

Literature References
PubMed ID Title Journal Year
11734551 Biochemical characterization of the human copper transporter Ctr1

Lee, J, Peña, MM, Nose, Y, Thiele, DJ

J Biol Chem 2002
17211682 A structural perspective on copper uptake in eukaryotes

De Feo, CJ, Aller, SG, Unger, VM

Biometals 2007
9207117 hCTR1: a human gene for copper uptake identified by complementation in yeast

Zhou, B, Gitschier, J

Proc Natl Acad Sci U S A 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
copper ion transmembrane transporter activity of SLC31A1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created