p-Y348-SYK binds VAV family

Stable Identifier
R-HSA-437932
Type
Reaction
Species
Homo sapiens
Compartment
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The SH2 region of Vav1 binds to Syk at a site including phosphorylated tyrosine Y348. Mutation of this residue to F abolishes binding and subsequent Vav1 phosphorylation. Vav2 has also been shown to bind Syk.

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