Membrane depolarization upon activation of Ca impermeable AMPA receptors

Stable Identifier
R-HSA-438037
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Membrane depolarization occurs due to glutamate dependent activation of Ca-impermeable AMPA receptors, which permits the influx of Na+ ions. The depolarization triggers the removal of Mg2+ from the NMDA receptor pore to facilitate its activation. Therefore, activation of AMPA receptors by glutamate precedes activation of NMDA receptors.

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
excitatory extracellular ligand-gated ion channel activity of Ca impermeable AMPA receptor ligand complex [plasma membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
Cross References
Rhea
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