NOTCH1 Coactivator Complex binds promoters of HEY genes

Stable Identifier
R-HSA-4396382
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RBPJ binding sites in the promoters of HEY1, HEY2 and HEYL genes are conserved between humans and mice (Maier and Gessler 2000), and human NICD1 was directly shown to bind human HEY2 and HEYL promoters (Arnett et al. 2010).

Literature References
PubMed ID Title Journal Year
10964718 Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes

Maier, MM, Gessler, M

Biochem Biophys Res Commun 2000
20972443 Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes

Arnett, KL, Hass, M, McArthur, DG, Ilagan, MXG, Aster, JC, Kopan, R, Blacklow, SC

Nat Struct Mol Biol 2010
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