NOTCH1 PEST domain mutants bind MYC promoter

Stable Identifier
R-HSA-4396393
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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NICD1 PEST domain mutant coactivator complexes are expected to bind MYC promoter in a similar manner to the wild-type NOTCH1 Coactivator Complex (Palomero et al. 2006).

Literature References
PubMed ID Title Journal Year
17114293 NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

Palomero, T, Lim, WK, Odom, DT, Sulis, ML, Real, PJ, Margolin, A, Barnes, KC, O'Neil, J, Neuberg, D, Weng, AP, Aster, JC, Sigaux, F, Soulier, J, Look, AT, Young, RA, Califano, A, Ferrando, AA

Proc Natl Acad Sci U S A 2006
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created