NOTCH1 PEST domain mutants bind MYC promoter

Stable Identifier
R-HSA-4396393
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NOTCH1 PEST domain mutants bind MYC promoter
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NICD1 PEST domain mutant coactivator complexes are expected to bind MYC promoter in a similar manner to the wild-type NOTCH1 Coactivator Complex (Palomero et al. 2006).
Literature References
PubMed ID Title Journal Year
17114293 NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

Sulis, ML, Look, AT, Palomero, T, Soulier, J, Ferrando, AA, Real, PJ, Neuberg, D, Lim, WK, Weng, AP, Sigaux, F, Margolin, A, Young, RA, O'Neil, J, Odom, DT, Aster, JC, Califano, A, Barnes, KC

Proc Natl Acad Sci U S A 2006
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Normal reaction
NOTCH1 Coactivator Complex binds MYC promoter (Homo sapiens)
Functional status

Gain of function of NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia DOID:5603
Authored
Orlic-Milacic, M  (2013-01-04)
Reviewed
Haw, R  (2013-02-10)
Created
Orlic-Milacic, M  (2013-08-23)
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