Reactome | NLK [cytosol]

NLK [cytosol]

Stable Identifier

R-HSA-4411330

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

LAK1

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Locations in the PathwayBrowser for interactor UniProt:Q96PM5 RCHY1

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External Reference Information

External Reference

UniProt:Q9UBE8 NLK

Gene Names

NLK, LAK1

Chain

chain:1-527

Reference Genes

BioGPS Gene:51701 NLK

COSMIC (genes):NLK NLK

CTD Gene:51701 NLK

dbSNP Gene:51701 NLK

ENSEMBL:ENSG00000087095 NLK

HGNC:29858 NLK

KEGG:hsa:51701 NLK

Monarch:51701 NLK

NCBI Gene:51701 NLK

OMIM:609476 NLK

UCSC:Q9UBE8 NLK

Reference Transcript

RefSeq:NM_016231.4 NLK

Other Identifiers

11719992_a_at

11719993_x_at

11719994_a_at

16832405

218318_PM_s_at

218318_s_at

222589_PM_at

222589_at

222590_PM_s_at

222590_s_at

238624_PM_at

238624_at

3715369

3715370

3715371

3715372

3715373

3715374

3715375

3715378

3715393

3715394

3715399

3715412

3715413

3715414

3715415

3715418

3715421

3715422

3715424

3715425

3715426

3715427

3715428

3715429

3715430

3715431

3715432

3715433

3715434

49096_at

51701

58846_s_at

65864_at

8005814

A_14_P136220

A_14_P139734

A_23_P15647

A_33_P3327108

GE58709

GO:0000165

GO:0000287

GO:0003824

GO:0004672

GO:0004674

GO:0004707

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006468

GO:0007165

GO:0007179

GO:0007223

GO:0016055

GO:0016740

GO:0018107

GO:0030178

GO:0031625

GO:0035556

GO:0042169

GO:0043226

GO:0046872

GO:0050821

GO:0071470

GO:0106310

GO:0140096

GO:0140297

GO:1904262

GO:1904894

HMNXSV003015184

HMNXSV003030410

Hs.3532.0.S3_3p_at

Hs.98505.0.A1_3p_at

ILMN_1772814

PH_hs_0000419

TC17000315.hg

g5917731_3p_a_at

g7706444_3p_a_at

Participates

as an output of

NLK mRNA translation controlled by miR-92b (Homo sapiens)

as an input of

Activation of NLK (Homo sapiens)

Other forms of this molecule

p-T298-NLK [cytosol]

p-T298-NLK [nucleoplasm]

Inferred To

Homologues of NLK [cytosol] (Saccharomyces cerevisiae)

Homologues of NLK [cytosol] (Schizosaccharomyces pombe)

NLK [cytosol] (Bos taurus)

NLK [cytosol] (Caenorhabditis elegans)

NLK [cytosol] (Canis familiaris)

NLK [cytosol] (Dictyostelium discoideum)

NLK [cytosol] (Drosophila melanogaster)

NLK [cytosol] (Gallus gallus)

NLK [cytosol] (Mus musculus)

NLK [cytosol] (Plasmodium falciparum)

NLK [cytosol] (Rattus norvegicus)

NLK [cytosol] (Saccharomyces cerevisiae)

NLK [cytosol] (Schizosaccharomyces pombe)

NLK [cytosol] (Sus scrofa)

NLK [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_057315.3

ZINC - World Drugs

NLK_HUMAN

Guide to Pharmacology - Targets

2125

OpenTargets

ENSG00000087095

ENSEMBL

ENSP00000384625

ZINC - FDA approved

NLK_HUMAN

ZINC - Substances

NLK_HUMAN

ZINC - Biogenic

NLK_HUMAN

ZINC target

Q9UBE8

PRO

Q9UBE8

ZINC - Investigational

NLK_HUMAN

IntEnz

2.7.11.24

HPA

ENSG00000087095-NLK

Pharos - Targets

Q9UBE8

ZINC - Predictions - Purchasable

NLK_HUMAN

HMDB Protein

HMDBP01158

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.781	7
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.719	6
UniProt:P54253 ATX1			0.666	4
UniProt:Q9H4I2 ZHX3			0.666	4
UniProt:Q5U5X8 F222A			0.643	4
UniProt:Q96PM5 RCHY1	2	RCHY1 [cytosol] (R-HSA-976013) RCHY1 [nucleoplasm] (R-HSA-5655134)	0.632	5
UniProt:O43318 MAP3K7	10	PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) MAP3K7 [plasma membrane] (R-HSA-9012677) p-T187-MAP3K7 [cytosol] (R-HSA-206014) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) p-MAP3K7 [cytosol] (R-HSA-168163) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.569	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q9BYR5 KRTAP4-2	1	KRTAP4-2 [cytosol] (R-HSA-6809948)	0.556	3
IntAct:EBI-16436789 CCSB ORF ID			0.556	3
UniProt:Q9H4I2-2 ZHX3			0.556	3
UniProt:Q9UHB4 NDOR1	1	NDOR1 [cytosol] (R-HSA-2564776)	0.556	3
UniProt:Q6L8G9 KRTAP5-6	1	KRTAP5-6 [cytosol] (R-HSA-6810276)	0.556	3
UniProt:Q2TAL8 QRIC1			0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q9UPX8 SHANK2	1	SHANK2 [cytosol] (R-HSA-6794265)	0.527	2
UniProt:Q9NZN8 CNOT2	1	CNOT2 [cytosol] (R-HSA-429902)	0.527	2
UniProt:Q9UHF7 TRPS1			0.527	2
UniProt:Q9H6R7 WDCP	2	WDCP(1-680)-p-7Y-ALK(1061-1620) fusion [cytosol] (R-HSA-9700468) WDCP(1-680)-ALK(1061-1620) fusion [cytosol] (R-HSA-9700460)	0.527	2
UniProt:Q8WU58 F222B			0.527	2
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [cytosol] (R-HSA-8982823) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.462	2

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