Binding of TCF/LEF:CTNNB1 to target gene promoters

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R-HSA-4411364
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Homo sapiens
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The genes regulated by beta-catenin and TCF/LEF are involved in a diverse range of functions in cellular proliferation, differentiation, embryogenesis and tissue homeostasis, and include transcription factors, cell cycle regulators, growth factors, proteinases and inflammatory cytokines, among others (reviewed in Vlad et al, 2008). A number of WNT signaling components are themselves positively or negatively regulated targets of TCF/LEF-dependent transcription, establishing feedback loops to enhance or restrict signaling (see for instance, Khan et al 2007; Chamorro et al, 2005; Roose et al, 1999; Lustig et al, 2002). Other than a few of these general feedback targets (e.g. Axin2), most target genes are cell- and/or tissue-specific. A list of WNT/beta-catenin-dependent target genes is maintained at http://www.standford.edu/group/nusselab/cgi-bin/wnt/target_genes.

Literature References
PubMed ID Title Journal Year
11809809 Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors

Lustig, B, Jerchow, B, Sachs, M, Weiler, S, Pietsch, T, Karsten, U, van De Wetering, M, Clevers, HC, Schlag, PM, Birchmeier, W, Behrens, J

Mol. Cell. Biol. 2002
18160255 The first five years of the Wnt targetome

Vlad, A, Röhrs, S, Klein-Hitpass, L, Müller, O

Cell. Signal. 2008
15592430 FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development

Chamorro, MN, Schwartz, DR, Vonica, A, Brivanlou, AH, Cho, KR, Varmus, HE

EMBO J. 2005
10489374 Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1

Roose, J, Huls, G, van Beest, M, Moerer, P, van der Horn, K, Goldschmeding, R, Logtenberg, T, Clevers, HC

Science 1999
17698587 Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor

Khan, Z, Vijayakumar, S, de la Torre, TV, Rotolo, S, Bafico, A

Mol. Cell. Biol. 2007
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