Reactome | pT155,S166-LEF1 [nucleoplasm]

pT155,S166-LEF1 [nucleoplasm]

Stable Identifier

R-HSA-4411389

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Lymphoid enhancer-binding factor 1, LEF1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UJU2 LEF1

Gene Names

LEF1

Chain

chain:1-399

Reference Genes

BioGPS Gene:51176 LEF1

COSMIC (genes):LEF1 LEF1

CTD Gene:51176 LEF1

dbSNP Gene:51176 LEF1

ENSEMBL:ENSG00000138795.10 LEF1

HGNC:6551 LEF1

KEGG Gene (Homo sapiens):51176 LEF1

Monarch:51176 LEF1

NCBI Gene:51176 LEF1

UCSC:Q9UJU2 LEF1

Reference Transcript

Other Identifiers

0006220270

11726332_a_at

11726333_s_at

11736566_a_at

11736567_a_at

11736568_x_at

11746635_a_at

11746636_a_at

11747931_a_at

11747932_x_at

16978834

210948_PM_s_at

210948_s_at

221557_PM_s_at

221557_s_at

221558_PM_s_at

221558_s_at

240343_PM_at

240343_at

2781140

2781141

2781142

2781143

2781144

2781151

2781152

2781154

2781159

2781160

2781161

2781162

2781164

2781166

2781168

2781196

2781197

2781198

2781199

2781201

2781202

2781203

2781204

2781205

2781206

36021_at

51176

76742_at

8102232

90453_at

A_23_P213045

A_24_P20630

GE534770

GE56173

GE86893

GO:0000122

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0000987

GO:0001222

GO:0001227

GO:0001228

GO:0001569

GO:0001649

GO:0001756

GO:0001837

GO:0001944

GO:0002040

GO:0002376

GO:0003677

GO:0003682

GO:0003700

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005667

GO:0005737

GO:0006310

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0007155

GO:0008013

GO:0008284

GO:0008301

GO:0010628

GO:0010718

GO:0012501

GO:0016055

GO:0021542

GO:0021766

GO:0021861

GO:0021873

GO:0021943

GO:0022407

GO:0022408

GO:0022409

GO:0022414

GO:0023052

GO:0030111

GO:0030154

GO:0030177

GO:0030223

GO:0030326

GO:0030331

GO:0030335

GO:0030509

GO:0030854

GO:0030879

GO:0032696

GO:0032713

GO:0032714

GO:0032991

GO:0032993

GO:0033153

GO:0036211

GO:0042100

GO:0042393

GO:0042475

GO:0042826

GO:0043066

GO:0043226

GO:0043392

GO:0043565

GO:0043586

GO:0043923

GO:0043966

GO:0043967

GO:0045063

GO:0045295

GO:0045588

GO:0045597

GO:0045843

GO:0045892

GO:0045893

GO:0045944

GO:0046632

GO:0048341

GO:0048468

GO:0048856

GO:0048870

GO:0050767

GO:0050877

GO:0050909

GO:0060033

GO:0060070

GO:0060325

GO:0060326

GO:0060561

GO:0060710

GO:0061153

GO:0062009

GO:0070016

GO:0070742

GO:0071345

GO:0071353

GO:0071864

GO:0071866

GO:0090068

GO:0090575

GO:0097043

GO:0098772

GO:0140416

GO:1902262

GO:1902732

GO:1904019

GO:1990837

GO:1990907

HMNXSV003037301

Hs.125132.0.A1_3p_at

Hs.44865.1.A1_3p_a_at

ILMN_1679185

PH_hs_0003252

TC04001459.hg

g11024343_3p_a_at

g9858157_3p_a_at

Participates

as a member of

p-TCF/LEF [nucleoplasm] (Homo sapiens)

Other forms of this molecule

LEF1 [nucleoplasm]

Inferred To

phospho-pop-1 [nucleoplasm] (Caenorhabditis elegans)

phospho-LEF1 [nucleoplasm] (Bos taurus)

phospho-LEF1 [nucleoplasm] (Gallus gallus)

phospho-LEF1 [nucleoplasm] (Sus scrofa)

phospho-pan [nucleoplasm] (Drosophila melanogaster)

phospho-lef1 [nucleoplasm] (Xenopus tropicalis)

phospho-pT155,S166-LEF1 [nucleoplasm] (Canis familiaris)

phospho-pT155,S166-LEF1 [nucleoplasm] (Danio rerio)

phospho-Lef1 [nucleoplasm] (Mus musculus)

phospho-Lef1 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-threonine at 155

Coordinate

155

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 166

Coordinate

166

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001124186.1, NP_001159591.1, NP_001124185.1, NP_057353.1

OpenTargets

ENSG00000138795

ZINC - Substances

LEF1_HUMAN

GeneCards

Q9UJU2

HPA

ENSG00000138795-LEF1

ZINC target

Q9UJU2

Ensembl

ENST00000438313, ENST00000506680, ENST00000379951, ENSP00000422334, ENSP00000422840, ENSP00000265165, ENSG00000138795, ENSP00000369284, ENSP00000406176, ENST00000510624, ENST00000265165

PRO

Q9UJU2

Pharos - Targets

Q9UJU2

Orphanet

24667

ZINC - Predictions - Purchasable

LEF1_HUMAN

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.893	10
UniProt:P08069 IGF1R	3	IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.576	5
UniProt:Q16236 NFE2L2	12	p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) ub-NFE2L2 [cytosol] (R-HSA-9758077) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109)	0.508	3
UniProt:P49789 FHIT			0.499	2