Reactome | pT155,S166-LEF1 [nucleoplasm]

pT155,S166-LEF1 [nucleoplasm]

Stable Identifier

R-HSA-4411389

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Lymphoid enhancer-binding factor 1, LEF1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UJU2 LEF1

Gene Names

LEF1

Chain

chain:1-399

Reference Genes

BioGPS Gene:51176 LEF1

COSMIC (genes):LEF1 LEF1

CTD Gene:51176 LEF1

dbSNP Gene:51176 LEF1

ENSEMBL:ENSG00000138795 LEF1

HGNC:6551 LEF1

KEGG:hsa:51176 LEF1

Monarch:51176 LEF1

NCBI Gene:51176 LEF1

OMIM:153245 LEF1

UCSC:Q9UJU2 LEF1

Reference Transcript

Other Identifiers

11726332_a_at

11726333_s_at

11736566_a_at

11736567_a_at

11736568_x_at

11746635_a_at

11746636_a_at

11747931_a_at

11747932_x_at

16978834

210948_PM_s_at

210948_s_at

221557_PM_s_at

221557_s_at

221558_PM_s_at

221558_s_at

240343_PM_at

240343_at

2781140

2781141

2781142

2781143

2781144

2781151

2781152

2781153

2781154

2781155

2781156

2781157

2781159

2781160

2781161

2781162

2781163

2781164

2781165

2781166

2781168

2781196

2781197

2781198

2781199

2781201

2781202

2781203

2781204

2781205

2781206

36021_at

51176

76742_at

8102232

90453_at

A_23_P213045

A_24_P20630

GE534770

GE56173

GE86893

GO:0000122

GO:0000785

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0000987

GO:0001222

GO:0001227

GO:0001228

GO:0001569

GO:0001649

GO:0001756

GO:0001837

GO:0001944

GO:0002040

GO:0002376

GO:0003677

GO:0003682

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005737

GO:0006310

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0007155

GO:0008013

GO:0008301

GO:0010628

GO:0010718

GO:0012501

GO:0016055

GO:0021542

GO:0021766

GO:0021861

GO:0021873

GO:0021943

GO:0022407

GO:0030111

GO:0030154

GO:0030177

GO:0030223

GO:0030326

GO:0030331

GO:0030335

GO:0030509

GO:0030854

GO:0030879

GO:0032696

GO:0032713

GO:0032714

GO:0032993

GO:0033153

GO:0042100

GO:0042475

GO:0042826

GO:0043066

GO:0043226

GO:0043392

GO:0043565

GO:0043586

GO:0043923

GO:0045063

GO:0045295

GO:0045588

GO:0045597

GO:0045843

GO:0045892

GO:0045893

GO:0045944

GO:0046632

GO:0048341

GO:0048468

GO:0048856

GO:0048870

GO:0050767

GO:0050877

GO:0050909

GO:0060033

GO:0060070

GO:0060325

GO:0060326

GO:0060561

GO:0060710

GO:0061153

GO:0062009

GO:0070016

GO:0070742

GO:0071168

GO:0071345

GO:0071353

GO:0071864

GO:0071866

GO:0090068

GO:0090575

GO:0098772

GO:0140110

GO:0140416

GO:1901331

GO:1902262

GO:1902732

GO:1904019

GO:1990837

GO:1990907

HMNXSV003037301

Hs.125132.0.A1_3p_at

Hs.44865.1.A1_3p_a_at

ILMN_1679185

PH_hs_0003252

TC04001459.hg

g11024343_3p_a_at

g9858157_3p_a_at

Participates

as a member of

p-TCF/LEF [nucleoplasm] (Homo sapiens)

Other forms of this molecule

LEF1 [nucleoplasm]

Inferred To

phospho-pop-1 [nucleoplasm] (Caenorhabditis elegans)

phospho-LEF1 [nucleoplasm] (Bos taurus)

phospho-LEF1 [nucleoplasm] (Canis familiaris)

phospho-LEF1 [nucleoplasm] (Gallus gallus)

phospho-LEF1 [nucleoplasm] (Sus scrofa)

phospho-pan [nucleoplasm] (Drosophila melanogaster)

phospho-lef1 [nucleoplasm] (Danio rerio)

phospho-Lef1 [nucleoplasm] (Mus musculus)

phospho-Lef1 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-threonine at 155

Coordinate

155

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 166

Coordinate

166

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001124186.1, NP_001124185.1, NP_057353.1, NP_001159591.1

ENSEMBL

ENST00000438313, ENSP00000265165, ENST00000510624, ENSP00000406176, ENSG00000138795, ENST00000265165, ENST00000506680, ENSP00000422334, ENST00000379951, ENSP00000422840, ENSP00000369284

OpenTargets

ENSG00000138795

GeneCards

LEF1

HPA

ENSG00000138795-LEF1

ZINC - Substances

LEF1_HUMAN

ZINC target

Q9UJU2

PRO

Q9UJU2

Pharos - Targets

Q9UJU2

ZINC - Predictions - Purchasable

LEF1_HUMAN

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.893	10
UniProt:Q96LA8 PRMT6	1	PRMT6 [nucleoplasm] (R-HSA-5226884)	0.641	3
UniProt:P08069 IGF1R	3	IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.576	5
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.508	3
UniProt:P49789 FHIT			0.499	2