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pT155,S166-LEF1 [nucleoplasm]
Stable Identifier
R-HSA-4411389
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Lymphoid enhancer-binding factor 1, LEF1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
NLK phosphorylates TCF/LEF (Homo sapiens)
p-TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
p-TCF/LEF [nucleoplasm] (Homo sapiens)
pT155,S166-LEF1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UJU2 LEF1
Gene Names
LEF1
Chain
chain:1-399
Reference Genes
BioGPS Gene:51176 LEF1
COSMIC (genes):LEF1 LEF1
CTD Gene:51176 LEF1
dbSNP Gene:51176 LEF1
ENSEMBL:ENSG00000138795 LEF1
HGNC:6551 LEF1
KEGG:hsa:51176 LEF1
Monarch:51176 LEF1
NCBI Gene:51176 LEF1
OMIM:153245 LEF1
UCSC:Q9UJU2 LEF1
Reference Transcript
RefSeq:NM_016269.4 LEF1
RefSeq:NM_001166119.1 LEF1
RefSeq:NM_001130714.2 LEF1
RefSeq:NM_001130713.2 LEF1
Other Identifiers
11726332_a_at
11726333_s_at
11736566_a_at
11736567_a_at
11736568_x_at
11746635_a_at
11746636_a_at
11747931_a_at
11747932_x_at
16978834
210948_PM_s_at
210948_s_at
221557_PM_s_at
221557_s_at
221558_PM_s_at
221558_s_at
240343_PM_at
240343_at
2781140
2781141
2781142
2781143
2781144
2781151
2781152
2781153
2781154
2781155
2781156
2781157
2781159
2781160
2781161
2781162
2781163
2781164
2781165
2781166
2781168
2781196
2781197
2781198
2781199
2781201
2781202
2781203
2781204
2781205
2781206
36021_at
51176
76742_at
8102232
90453_at
A_23_P213045
A_24_P20630
GE534770
GE56173
GE86893
GO:0000122
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001222
GO:0001227
GO:0001228
GO:0001569
GO:0001649
GO:0001756
GO:0001837
GO:0001944
GO:0002040
GO:0002376
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0006310
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0007155
GO:0008013
GO:0008301
GO:0010628
GO:0010718
GO:0012501
GO:0016055
GO:0021542
GO:0021766
GO:0021861
GO:0021873
GO:0021943
GO:0022407
GO:0030111
GO:0030154
GO:0030177
GO:0030223
GO:0030326
GO:0030331
GO:0030335
GO:0030509
GO:0030854
GO:0030879
GO:0032696
GO:0032713
GO:0032714
GO:0032993
GO:0033153
GO:0042100
GO:0042475
GO:0042826
GO:0043066
GO:0043226
GO:0043392
GO:0043565
GO:0043586
GO:0043923
GO:0045063
GO:0045295
GO:0045588
GO:0045597
GO:0045843
GO:0045892
GO:0045893
GO:0045944
GO:0046632
GO:0048341
GO:0048468
GO:0048856
GO:0048870
GO:0050767
GO:0050877
GO:0050909
GO:0060033
GO:0060070
GO:0060325
GO:0060326
GO:0060561
GO:0060710
GO:0061153
GO:0062009
GO:0070016
GO:0070742
GO:0071168
GO:0071345
GO:0071353
GO:0071864
GO:0071866
GO:0090068
GO:0090575
GO:0098772
GO:0140110
GO:0140416
GO:1901331
GO:1902262
GO:1902732
GO:1904019
GO:1990837
GO:1990907
HMNXSV003037301
Hs.125132.0.A1_3p_at
Hs.44865.1.A1_3p_a_at
ILMN_1679185
PH_hs_0003252
TC04001459.hg
g11024343_3p_a_at
g9858157_3p_a_at
Participates
as a member of
p-TCF/LEF [nucleoplasm] (Homo sapiens)
Other forms of this molecule
LEF1 [nucleoplasm]
Inferred To
phospho-pop-1 [nucleoplasm]
(Caenorhabditis elegans)
phospho-LEF1 [nucleoplasm]
(Bos taurus)
phospho-LEF1 [nucleoplasm]
(Canis familiaris)
phospho-LEF1 [nucleoplasm]
(Gallus gallus)
phospho-LEF1 [nucleoplasm]
(Sus scrofa)
phospho-pan [nucleoplasm]
(Drosophila melanogaster)
phospho-lef1 [nucleoplasm]
(Danio rerio)
phospho-Lef1 [nucleoplasm]
(Mus musculus)
phospho-Lef1 [nucleoplasm]
(Rattus norvegicus)
Modified Residues
Name
O-phospho-L-threonine at 155
Coordinate
155
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 166
Coordinate
166
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001124186.1
,
NP_001124185.1
,
NP_057353.1
,
NP_001159591.1
ENSEMBL
ENST00000438313
,
ENSP00000265165
,
ENST00000510624
,
ENSP00000406176
,
ENSG00000138795
,
ENST00000265165
,
ENST00000506680
,
ENSP00000422334
,
ENST00000379951
,
ENSP00000422840
,
ENSP00000369284
OpenTargets
ENSG00000138795
GeneCards
LEF1
HPA
ENSG00000138795-LEF1
ZINC - Substances
LEF1_HUMAN
ZINC target
Q9UJU2
PRO
Q9UJU2
Pharos - Targets
Q9UJU2
ZINC - Predictions - Purchasable
LEF1_HUMAN
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
0.893
10
UniProt:Q96LA8 PRMT6
1
PRMT6 [nucleoplasm]
(R-HSA-5226884)
0.641
3
UniProt:P08069 IGF1R
3
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
0.576
5
UniProt:Q16236 NFE2L2
13
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
0.508
3
UniProt:P49789 FHIT
0.499
2
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