Reactome | p-T298-NLK [cytosol]

p-T298-NLK [cytosol]

Stable Identifier

R-HSA-4411398

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

LAK1

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External Reference Information

External Reference

UniProt:Q9UBE8 NLK

Gene Names

NLK, LAK1

Chain

chain:1-527

Reference Genes

BioGPS Gene:51701 NLK

COSMIC (genes):NLK NLK

CTD Gene:51701 NLK

dbSNP Gene:51701 NLK

ENSEMBL:ENSG00000087095.13 NLK

HGNC:29858 NLK

KEGG Gene (Homo sapiens):51701 NLK

Monarch:51701 NLK

NCBI Gene:51701 NLK

OMIM:609476 NLK

UCSC:Q9UBE8 NLK

Reference Transcript

RefSeq:NM_016231.4 NLK

Other Identifiers

0006840446

11719992_a_at

11719993_x_at

11719994_a_at

16832405

218318_PM_s_at

218318_s_at

222589_PM_at

222589_at

222590_PM_s_at

222590_s_at

3715369

3715370

3715371

3715372

3715373

3715374

3715375

3715393

3715394

3715399

3715412

3715413

3715414

3715415

3715418

3715421

3715422

3715425

3715426

3715427

3715428

3715429

3715430

3715431

3715432

3715433

3715434

51701

58846_s_at

65864_at

8005814

A_14_P136220

A_14_P139734

A_23_P15647

A_33_P3327108

GE58709

GO:0000165

GO:0000166

GO:0000287

GO:0003674

GO:0004672

GO:0004674

GO:0004707

GO:0004712

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006468

GO:0007179

GO:0007223

GO:0008134

GO:0008150

GO:0016055

GO:0016301

GO:0016310

GO:0016740

GO:0018107

GO:0019899

GO:0023052

GO:0030178

GO:0031625

GO:0035556

GO:0036211

GO:0042169

GO:0042501

GO:0043167

GO:0043226

GO:0043231

GO:0046777

GO:0046872

GO:0050821

GO:0106310

GO:0140297

HMNXSV003015184

Hs.3532.0.S3_3p_at

ILMN_1772814

PH_hs_0000419

TC17000315.hg

g5917731_3p_a_at

g7706444_3p_a_at

Participates

as a component of

pT298-NLK dimer [cytosol] (Homo sapiens)

Other forms of this molecule

NLK [cytosol]

p-T298-NLK [nucleoplasm]

Inferred To

phospho-gska-3 [cytosol] (Caenorhabditis elegans)

Homologues of p-T298-NLK [cytosol] (Caenorhabditis elegans)

Homologues of p-T298-NLK [cytosol] (Dictyostelium discoideum)

phospho-p-T298-NLK [cytosol] (Bos taurus)

phospho-p-T298-NLK [cytosol] (Caenorhabditis elegans)

phospho-p-T298-NLK [cytosol] (Canis familiaris)

phospho-p-T298-NLK [cytosol] (Danio rerio)

phospho-p-T298-NLK [cytosol] (Dictyostelium discoideum)

phospho-p-T298-NLK [cytosol] (Drosophila melanogaster)

phospho-p-T298-NLK [cytosol] (Gallus gallus)

phospho-p-T298-NLK [cytosol] (Mus musculus)

phospho-p-T298-NLK [cytosol] (Plasmodium falciparum)

phospho-p-T298-NLK [cytosol] (Rattus norvegicus)

phospho-p-T298-NLK [cytosol] (Sus scrofa)

phospho-p-T298-NLK [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-threonine at 298

Coordinate

298

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_057315.3

ZINC - World Drugs

NLK_HUMAN

Guide to Pharmacology - Targets

2125

OpenTargets

ENSG00000087095

ZINC - FDA approved

NLK_HUMAN

ZINC - Substances

NLK_HUMAN

ZINC - Biogenic

NLK_HUMAN

ZINC target

Q9UBE8

PRO

Q9UBE8

ZINC - Investigational

NLK_HUMAN

GeneCards

Q9UBE8

HPA

ENSG00000087095-NLK

Ensembl

ENSG00000087095, ENST00000407008, ENSP00000384625

Pharos - Targets

Q9UBE8

ZINC - Predictions - Purchasable

NLK_HUMAN

HMDB Protein

HMDBP01158

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.781	7
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.719	6
UniProt:P54253 ATX1			0.666	4
UniProt:Q9H4I2 ZHX3			0.666	4
UniProt:Q96PM5 RCHY1	2	RCHY1 [cytosol] (R-HSA-976013) RCHY1 [nucleoplasm] (R-HSA-5655134)	0.632	5
UniProt:O43318 MAP3K7	10	PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) MAP3K7 [plasma membrane] (R-HSA-9012677) p-T187-MAP3K7 [cytosol] (R-HSA-206014) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) p-MAP3K7 [cytosol] (R-HSA-168163) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.569	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
UniProt:Q6L8G9 KRTAP5-6	1	KRTAP5-6 [cytosol] (R-HSA-6810276)	0.556	3
UniProt:Q2TAL8 QRIC1			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q9BYR5 KRTAP4-2	1	KRTAP4-2 [cytosol] (R-HSA-6809948)	0.556	3
IntAct:EBI-16436789 CCSB ORF ID			0.556	3
UniProt:Q9H4I2-2 ZHX3			0.556	3
UniProt:Q9UHB4 NDOR1	1	NDOR1 [cytosol] (R-HSA-2564776)	0.556	3
UniProt:Q5U5X8 F222A			0.527	2
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.462	2

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