Reactome | p-T298-NLK [cytosol]

p-T298-NLK [cytosol]

Stable Identifier

R-HSA-4411398

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

LAK1

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External Reference Information

External Reference

UniProt:Q9UBE8 NLK

Gene Names

NLK, LAK1

Chain

chain:1-527

Reference Genes

BioGPS Gene:51701 NLK

COSMIC (genes):NLK NLK

CTD Gene:51701 NLK

dbSNP Gene:51701 NLK

ENSEMBL:ENSG00000087095 NLK

HGNC:29858 NLK

KEGG Gene (Homo sapiens):51701 NLK

Monarch:51701 NLK

NCBI Gene:51701 NLK

OMIM:609476 NLK

UCSC:Q9UBE8 NLK

Reference Transcript

RefSeq:NM_016231.4 NLK

Other Identifiers

0006840446

11719992_a_at

11719993_x_at

11719994_a_at

16832405

218318_s_at

222589_at

222590_s_at

3715369

3715370

3715371

3715372

3715373

3715374

3715375

3715393

3715394

3715399

3715412

3715413

3715414

3715415

3715418

3715421

3715422

3715425

3715426

3715427

3715428

3715429

3715430

3715431

3715432

3715433

3715434

51701

58846_s_at

65864_at

8005814

A_14_P136220

A_14_P139734

A_23_P15647

A_33_P3327108

GE58709

GO:0000165

GO:0000166

GO:0000287

GO:0003674

GO:0004672

GO:0004674

GO:0004707

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006464

GO:0006468

GO:0007165

GO:0007179

GO:0007223

GO:0007267

GO:0008134

GO:0008150

GO:0009058

GO:0010468

GO:0016055

GO:0016301

GO:0016310

GO:0016740

GO:0018107

GO:0019899

GO:0030178

GO:0031625

GO:0034641

GO:0035556

GO:0042169

GO:0042501

GO:0043167

GO:0043226

GO:0046777

GO:0046872

GO:0050821

HMNXSV003015184

Hs.3532.0.S3_3p_at

ILMN_1772814

PH_hs_0000419

TC17000315.hg

g5917731_3p_a_at

g7706444_3p_a_at

Participates

as a component of

pT298-NLK dimer [cytosol] (Homo sapiens)

Other forms of this molecule

NLK [cytosol]

p-T298-NLK [nucleoplasm]

Inferred To

phospho-Nlk [cytosol] (Mus musculus)

phospho-Nlk [cytosol] (Rattus norvegicus)

phospho-SLT2 [cytosol] (Saccharomyces cerevisiae)

phospho-erkA [cytosol] (Dictyostelium discoideum)

phospho-spm1 [cytosol] (Schizosaccharomyces pombe)

phospho-lit-1 [cytosol] (Caenorhabditis elegans)

phospho-SMK1 [cytosol] (Saccharomyces cerevisiae)

phospho-nlk2 [cytosol] (Danio rerio)

phospho-nmo [cytosol] (Drosophila melanogaster)

Homologues of p-T298-NLK [cytosol] (Dictyostelium discoideum)

Homologues of p-T298-NLK [cytosol] (Saccharomyces cerevisiae)

phospho-p-T298-NLK [cytosol] (Dictyostelium discoideum)

phospho-p-T298-NLK [cytosol] (Plasmodium falciparum)

phospho-NLK [cytosol] (Canis familiaris)

phospho-NLK [cytosol] (Gallus gallus)

phospho-NLK [cytosol] (Sus scrofa)

Modified Residues

Name

O-phospho-L-threonine at 298

Coordinate

298

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_057315.3

ZINC - World Drugs

NLK_HUMAN

OpenTargets

ENSG00000087095

ZINC - FDA approved

NLK_HUMAN

ZINC - Substances

NLK_HUMAN

ZINC - Biogenic

NLK_HUMAN

ZINC target

Q9UBE8

PRO

Q9UBE8

ZINC - Investigational

NLK_HUMAN

GeneCards

Q9UBE8

HPA

ENSG00000087095-NLK

Ensembl

ENSP00000384625, ENSG00000087095, ENST00000407008

ZINC - Predictions - Purchasable

NLK_HUMAN

HMDB Protein

HMDBP01158

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28799 GRN	2	GRN [extracellular region] (R-HSA-6806217) GRN [azurophil granule lumen] (R-HSA-6799168)	0.781	7
UniProt:Q13485 SMAD4	88	SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622) SMAD4 E417* [cytosol] (R-HSA-9675623) SMAD4 Y195* [cytosol] (R-HSA-9678462) SMAD4 E108* [cytosol] (R-HSA-9675640) SMAD4 S343* [cytosol] (R-HSA-9675641) SMAD4 E520* [cytosol] (R-HSA-9675636) SMAD4 G510* [cytosol] (R-HSA-9678452) SMAD4 G358* [cytosol] (R-HSA-9678453) SMAD4 E175* [cytosol] (R-HSA-9675637) SMAD4 E307* [cytosol] (R-HSA-9675639) SMAD4 E53* [cytosol] (R-HSA-9675633) SMAD4 S171* [cytosol] (R-HSA-9675634) SMAD4 G30* [cytosol] (R-HSA-9678450) SMAD4 G168* [cytosol] (R-HSA-9678451) SMAD4 Q366* [cytosol] (R-HSA-9675200) SMAD4 R135* [cytosol] (R-HSA-9675090) SMAD4 L146* [cytosol] (R-HSA-9678509) SMAD4 L440* [cytosol] (R-HSA-9678510) SMAD4 Q183* [cytosol] (R-HSA-9675176) SMAD4 Q289* [cytosol] (R-HSA-9675177) SMAD4 Q248* [cytosol] (R-HSA-9675178) SMAD4 Q249* [cytosol] (R-HSA-9675172) SMAD4 Q256* [cytosol] (R-HSA-9675173) SMAD4 Q239* [cytosol] (R-HSA-9675174) SMAD4 Q245* [cytosol] (R-HSA-9675175) SMAD4 Q224* [cytosol] (R-HSA-9675168) SMAD4 W509* [cytosol] (R-HSA-9678497) SMAD4 Q311* [cytosol] (R-HSA-9675169) SMAD4 W398* [cytosol] (R-HSA-9678498) SMAD4 Q250* [cytosol] (R-HSA-9675170) SMAD4 Q410* [cytosol] (R-HSA-9675196) SMAD4 Q534* [cytosol] (R-HSA-9675197) SMAD4 Q83* [cytosol] (R-HSA-9675199) SMAD4 Q448* [cytosol] (R-HSA-9675192) SMAD4 K428R [cytosol] (R-HSA-3311001) SMAD4 Q455* [cytosol] (R-HSA-9675193) SMAD4 R445* [cytosol] (R-HSA-9675065) SMAD4 Q442* [cytosol] (R-HSA-9675194) SMAD4 Q516* [cytosol] (R-HSA-9675195) SMAD4 C443* [cytosol] (R-HSA-9678523) SMAD4 Q334* [cytosol] (R-HSA-9675191) SMAD4 R361G [cytosol] (R-HSA-3310993) SMAD4 L172* [cytosol] (R-HSA-9678514) SMAD4 K122* [cytosol] (R-HSA-9678515) SMAD4 R361S [cytosol] (R-HSA-3310994) SMAD4 Y430* [cytosol] (R-HSA-9678476) SMAD4 Y260* [cytosol] (R-HSA-9678477) SMAD4 Y95* [cytosol] (R-HSA-9678478) SMAD4 Y322* [cytosol] (R-HSA-9678479) SMAD4 E321* [cytosol] (R-HSA-9675658) SMAD4 Y412* [cytosol] (R-HSA-9678469) SMAD4 R515* [cytosol] (R-HSA-3311012) SMAD4 Y328* [cytosol] (R-HSA-9678470) SMAD4 E33* [cytosol] (R-HSA-9675654) SMAD4 Y513* [cytosol] (R-HSA-9678471) SMAD4 E526* [cytosol] (R-HSA-9675648) SMAD4 S138* [cytosol] (R-HSA-9675649) SMAD4 Y276* [cytosol] (R-HSA-9678466) SMAD4 E205* [cytosol] (R-HSA-9675650) SMAD4 E49* [cytosol] (R-HSA-9675651) SMAD4 W101* [cytosol] (R-HSA-9678492) SMAD4 W268* [cytosol] (R-HSA-9678494) SMAD4 [nucleoplasm] (R-HSA-177103) SMAD4 [cytosol] (R-HSA-170862) RibC-SMAD4 [nucleoplasm] (R-HSA-2187323) SMAD4 W524* [cytosol] (R-HSA-9678491) SMAD4 W302* [cytosol] (R-HSA-9678490) SMAD4 S242* [cytosol] (R-HSA-9675167) SMAD4 Q116* [cytosol] (R-HSA-9675166)	0.719	6
UniProt:P54253 ATX1			0.666	4
UniProt:Q9H4I2 ZHX3			0.666	4
UniProt:Q96PM5 RCHY1	2	RCHY1 [nucleoplasm] (R-HSA-5655134) RCHY1 [cytosol] (R-HSA-976013)	0.632	5
UniProt:O43318 MAP3K7	10	p-MAP3K7 [cytosol] (R-HSA-168163) PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) p-T187-MAP3K7 [cytosol] (R-HSA-206014) MAP3K7 [plasma membrane] (R-HSA-9012677) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.569	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q9BYR5 KRTAP4-2	1	KRTAP4-2 [cytosol] (R-HSA-6809948)	0.556	3
IntAct:EBI-16436789 CCSB ORF ID			0.556	3
UniProt:Q9H4I2-2 ZHX3			0.556	3
UniProt:Q9UHB4 NDOR1	1	NDOR1 [cytosol] (R-HSA-2564776)	0.556	3
UniProt:Q2TAL8 QRIC1			0.556	3
UniProt:Q6L8G9 KRTAP5-6	1	KRTAP5-6 [cytosol] (R-HSA-6810276)	0.556	3
UniProt:Q5U5X8 F222A			0.527	2
UniProt:P40763 STAT3	10	p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [cytosol] (R-HSA-8982823) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.462	2

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