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p-T298-NLK [cytosol]
Stable Identifier
R-HSA-4411398
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
LAK1
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
Activation of NLK (Homo sapiens)
pT298-NLK dimer [cytosol] (Homo sapiens)
p-T298-NLK [cytosol] (Homo sapiens)
NLK translocates to nucleus (Homo sapiens)
pT298-NLK dimer [cytosol] (Homo sapiens)
p-T298-NLK [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBE8 NLK
Gene Names
NLK, LAK1
Chain
chain:1-527
Reference Genes
BioGPS Gene:51701 NLK
CTD Gene:51701 NLK
dbSNP Gene:51701 NLK
ENSEMBL:ENSG00000087095 NLK
HGNC:29858 NLK
KEGG Gene (Homo sapiens):51701 NLK
Monarch:51701 NLK
NCBI Gene:51701 NLK
OMIM:609476 NLK
UCSC:Q9UBE8 NLK
Reference Transcript
RefSeq:NM_016231.4 NLK
Other Identifiers
0006840446
04150+2.7.11.24
11719992_a_at
11719993_x_at
11719994_a_at
16832405
18192
218318_s_at
222589_at
222590_s_at
3715369
3715370
3715371
3715372
3715373
3715374
3715375
3715393
3715394
3715399
3715412
3715413
3715414
3715415
3715418
3715421
3715422
3715425
3715426
3715427
3715428
3715429
3715430
3715431
3715432
3715433
3715434
51701
56511
58846_s_at
65864_at
8005814
A0A024QZ12
A_14_P136220
A_14_P139734
A_23_P15647
A_33_P3327108
AAD56013
AAF04857
AAH64663
ABC40748
AF180819
AF197898
AK315315
BAG37718
BC064663
CCDS11224
CH471159
DQ316259
EAW51060
EAW51062
ENSG00000087095
ENSP00000384625
ENST00000407008
ENST00000407008.7
EntrezGene:51701
EntrezGene:NLK
g5917731_3p_a_at
g7706444_3p_a_at
GE58709
GO:0000165
GO:0000166
GO:0000287
GO:0003674
GO:0004672
GO:0004674
GO:0004707
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006355
GO:0006464
GO:0006468
GO:0007165
GO:0007179
GO:0007223
GO:0007267
GO:0008134
GO:0008150
GO:0009058
GO:0010468
GO:0016055
GO:0016301
GO:0016310
GO:0016740
GO:0018107
GO:0019899
GO:0030178
GO:0031625
GO:0034641
GO:0035556
GO:0042169
GO:0042501
GO:0043167
GO:0043226
GO:0046777
GO:0046872
GO:0050821
H0YD75
HGNC:29858
HPA018192
HPA056511
Hs.3532.0.S3_3p_at
ILMN_1772814
IPR000719
IPR003527
IPR008271
IPR011009
IPR017441
J3QSE9
MIM:609476
NLK
NLK-201
NM_016231
NP_057315
PF00069
PH_hs_0000419
SM00220
TC17000315.hg
UPI0000D48A70
XM_005257988
XP_005258045
XR_934482
Participant Of
hasComponent
pT298-NLK dimer [cytosol]
Other forms of this molecule
p-T298-NLK [nucleoplasm]
NLK [cytosol]
Inferred To
phospho-p-T298-NLK [cytosol] (Bos taurus)
phospho-p-T298-NLK [cytosol] (Caenorhabditis elegans)
phospho-p-T298-NLK [cytosol] (Canis familiaris)
phospho-p-T298-NLK [cytosol] (Danio rerio)
phospho-p-T298-NLK [cytosol] (Drosophila melanogaster)
phospho-p-T298-NLK [cytosol] (Gallus gallus)
phospho-p-T298-NLK [cytosol] (Mus musculus)
phospho-p-T298-NLK [cytosol] (Rattus norvegicus)
phospho-p-T298-NLK [cytosol] (Sus scrofa)
phospho-p-T298-NLK [cytosol] (Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-threonine at 298
Coordinate
298
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
ZINC - Investigational
NLK_HUMAN
RefSeq
NP_057315.3
ZINC - World Drugs
NLK_HUMAN
OpenTargets
ENSG00000087095
ZINC - FDA approved
NLK_HUMAN
ZINC - Substances
NLK_HUMAN
GeneCards
Q9UBE8
ZINC target
Q9UBE8
ZINC - Biogenic
NLK_HUMAN
PRO
Q9UBE8
ZINC - Predictions - Purchasable
NLK_HUMAN
HMDB Protein
HMDBP01158
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.781
7
UniProt:Q13485 SMAD4
18
SMAD4 K428T [cytosol]
(R-HSA-3311004)
SMAD4 P356R [cytosol]
(R-HSA-3310988)
SMAD4 D351del [cytosol]
(R-HSA-3310974)
SMAD4 R361H [cytosol]
(R-HSA-3310984)
SMAD4 P356L [cytosol]
(R-HSA-3310987)
SMAD4 A406T [cytosol]
(R-HSA-3311003)
SMAD4 D351Y [cytosol]
(R-HSA-3310970)
SMAD4 D351H [cytosol]
(R-HSA-3310965)
SMAD4 [nucleoplasm]
(R-HSA-177103)
SMAD4 [cytosol]
(R-HSA-170862)
RibC-SMAD4 [nucleoplasm]
(R-HSA-2187323)
SMAD4 R361S [cytosol]
(R-HSA-3310994)
SMAD4 R361G [cytosol]
(R-HSA-3310993)
SMAD4 R515* [cytosol]
(R-HSA-3311012)
SMAD4 K428R [cytosol]
(R-HSA-3311001)
SMAD4 R515T [cytosol]
(R-HSA-3311008)
SMAD4 D351G [cytosol]
(R-HSA-3310967)
SMAD4 R361C [cytosol]
(R-HSA-3310983)
0.719
6
UniProt:Q9H4I2 ZHX3
0.666
4
UniProt:Q96PM5 RCHY1
2
RCHY1 [nucleoplasm]
(R-HSA-5655134)
RCHY1 [cytosol]
(R-HSA-976013)
0.632
5
UniProt:O43318 MAP3K7
10
MAP3K7 [plasma membrane]
(R-HSA-9012677)
PolyUb-MAP3K7 [cytosol]
(R-HSA-6782968)
p-MAP3K7 [cytosol]
(R-HSA-168163)
K63polyUb-34,158-TAK1 [cytosol]
(R-HSA-5607643)
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]
(R-HSA-5607649)
p-T187-MAP3K7 [cytosol]
(R-HSA-206014)
MAP3K7 [endosome membrane]
(R-HSA-450315)
p-T184,T187-MAP3K7 [endosome membrane]
(R-HSA-450332)
MAP3K7 [cytosol]
(R-HSA-168156)
p-T184,T187-MAP3K7 [cytosol]
(R-HSA-202527)
0.623
3
IntAct:EBI-10171679 386682
0.556
3
UniProt:P26371 KRTAP5-9
1
KRTAP5-9 [cytosol]
(R-HSA-6810265)
0.556
3
UniProt:Q6L8G9 KRTAP5-6
1
KRTAP5-6 [cytosol]
(R-HSA-6810276)
0.556
3
UniProt:Q2TAL8 QRIC1
0.556
3
UniProt:Q9BYR5 KRTAP4-2
1
KRTAP4-2 [cytosol]
(R-HSA-6809948)
0.556
3
UniProt:Q5U5X8 F222A
0.527
2
IntAct:EBI-17174885 KRTAP101
0.488
2
UniProt:Q9UHB4 NDOR1
1
NDOR1 [cytosol]
(R-HSA-2564776)
0.488
2
UniProt:Q9H4I2-2 ZHX3
0.488
2
UniProt:Q8NAX2 KDF1
0.488
2
UniProt:P40763 STAT3
10
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
STAT3 [cytosol]
(R-HSA-539044)
0.462
2
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