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NEDD8-AcM-UBE2M [cytosol]
Stable Identifier
R-HSA-4419896
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
NEDD8:UBC12
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Homo sapiens)
NEDD8-AcM-UBE2M:CUL9:RBX1 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CUL9:RBX1 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
Transfer of NEDD8 to AcM-UBE2M (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
CBL neddylates TGFBR2 (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
10207026
Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway
Yeh, ET
,
Gong, L
J. Biol. Chem.
1999
Participants
components
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(Homo sapiens)
G76-NEDD8-C111-AcM-UBE2M [cytosol]
(Homo sapiens)
Participates
as an input of
NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CBL neddylates TGFBR2 (Homo sapiens)
as a component of
NEDD8-AcM-UBE2M:CUL9:RBX1 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
as an output of
Transfer of NEDD8 to AcM-UBE2M (Homo sapiens)
Inferred To
NEDD8-AcM-UBE2M [cytosol]
(Bos taurus)
NEDD8-AcM-UBE2M [cytosol]
(Caenorhabditis elegans)
NEDD8-AcM-UBE2M [cytosol]
(Canis familiaris)
NEDD8-AcM-UBE2M [cytosol]
(Danio rerio)
NEDD8-AcM-UBE2M [cytosol]
(Dictyostelium discoideum)
NEDD8-AcM-UBE2M [cytosol]
(Drosophila melanogaster)
NEDD8-AcM-UBE2M [cytosol]
(Gallus gallus)
NEDD8-AcM-UBE2M [cytosol]
(Mus musculus)
NEDD8-AcM-UBE2M [cytosol]
(Plasmodium falciparum)
NEDD8-AcM-UBE2M [cytosol]
(Rattus norvegicus)
NEDD8-AcM-UBE2M [cytosol]
(Saccharomyces cerevisiae)
NEDD8-AcM-UBE2M [cytosol]
(Schizosaccharomyces pombe)
NEDD8-AcM-UBE2M [cytosol]
(Sus scrofa)
NEDD8-AcM-UBE2M [cytosol]
(Xenopus tropicalis)
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