SFKs phosphorylate PLCG1

Stable Identifier
R-HSA-4420121
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Activation of VEGFR2 has been shown to lead to direct binding and phosphorylation of PLC-gamma 1 (McLaughlin & Vries 2001). PLCG1 is tyrosine phosphorylated directly by VEGFR2 or through the Src kinases on four tyrosine residues, enhancing the activity of PLCG1.
Literature References
PubMed ID Title Journal Year
15879121 A new tyrosine phosphorylation site in PLC gamma 1: the role of tyrosine 775 in immune receptor signaling

Reischl, IG, Graham, L, DeBell, K, Rellahan, BL, Rawat, R, Serrano, CJ, Veri, MC, Bonvini, E

J. Immunol. 2005
11600407 Role of PLCgamma and Ca(2+) in VEGF- and FGF-induced choroidal endothelial cell proliferation

McLaughlin, AP, De Vries, GW

Am. J. Physiol., Cell Physiol. 2001
20807769 Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes

Hicks, SN, Sondek, J, Harden, TK, Gresset, A

J. Biol. Chem. 2010
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of SRC-1 [cytosol]

Orthologous Events
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