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VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane]
Stable Identifier
R-HSA-4420137
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
AXL autophosphorylates on Y779 and Y821 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Homo sapiens)
AXL binds SRC-1 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Homo sapiens)
Phosphorylation of SRC-1 (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Homo sapiens)
SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Homo sapiens)
p-6Y-VEGFR2 binds SH2D2A (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Homo sapiens)
p-AXL binds PI3K (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Homo sapiens)
Participants
components
SH2D2A [cytosol]
(Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane]
(Homo sapiens)
Participates
as an output of
p-6Y-VEGFR2 binds SH2D2A (Homo sapiens)
as an input of
SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Homo sapiens)
as a component of
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Homo sapiens)
Inferred To
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane]
(Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane]
(Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane]
(Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane]
(Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane]
(Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane]
(Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane]
(Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane]
(Sus scrofa)
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