ZIP6 and ZIP14 mediate zinc influx into cells

Stable Identifier
R-HSA-442317
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

The human gene SLC39A6 encodes the zinc transporter ZIP6 (LIV-1). The gene is oestrogen-regulated and has been implicated in metastatic breast cancer. ZIP6 mediates the transport of zinc into cells, is localized to the plasma membrane and is expressed mainly in hormonal tissues such as breast, prostate and brain (Taylor KM et al, 2003).

The human gene SLC39A14 encodes the zinc transporter ZIP14. This protein is ubiquitously expressed with higher expression seen in heart, liver and pancreas. ZIP14 is localized to the plasma membrane and mediates zinc influx into cells (Taylor KM et al, 2005).

Literature References
PubMed ID Title Journal Year
15642354 Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14

Taylor, KM, Morgan, HE, Johnson, A, Nicholson, RI

FEBS Lett 2005
12839489 Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters

Taylor, KM, Morgan, HE, Johnson, A, Hadley, LJ, Nicholson, RI

Biochem J 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
zinc ion transmembrane transporter activity of ZIP6/ZIP14 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed