Reactome: A Curated Pathway Database

hZIP10 mediates zinc influx into cells

Stable Identifier
R-HSA-442345
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The human gene SLC39A10 encodes the zinc transporter hZIP10. It is thought to be involved in the invasive behaviour of breast cancer cells where depletion of hZIP10 and intracellular zinc levels inhibit the migratory effects these cells (Kagara N et al, 2007). Functional characterization of this transporter was elucidated in the rat orthologue rZip10.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
zinc ion transmembrane transporter activity of SLC39A10 [plasma membrane] SLC39A10 [plasma membrane] zinc ion transmembrane transporter activity (0005385)
Inferred From
Cross References
Rhea