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Zinc influx into cells by the SLC39 gene family
Stable Identifier
R-HSA-442380
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Metal ion SLC transporters (Homo sapiens)
Zinc transporters (Homo sapiens)
Zinc influx into cells by the SLC39 gene family (Homo sapiens)
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The SLC39 gene family encode zinc transporters belonging to the ZIP (Zrt-, Irt-like proteins) family of metal ion transporters. All ZIPs transport metal ions into the cytoplasm of cells, be it across cellular membranes or from intracellular compartments. To date, there are 14 human SLC39 genes that encode the zinc transporters hZIP1-14. There are 9 members which belong to a subfamily of the ZIPs called the LZTs (LIV-1 subfamily of ZIP zinc transporters) (Taylor KM and Nicholson RI, 2003). Of these 14 proteins, four (hZIP9, 11, 12 and 13) have no function determined yet (Eide DJ, 2004).
Literature References
PubMed ID
Title
Journal
Year
12748861
The SLC39 family of metal ion transporters
Eide, DJ
Pflugers Arch
2004
12659941
The LZT proteins; the LIV-1 subfamily of zinc transporters
Taylor, KM
,
Nicholson, RI
Biochim Biophys Acta
2003
Participants
Events
SLC39A1-4 transports Zn2+ from extracellular region to cytosol
(Homo sapiens)
hZIP5 mediates zinc uptake by cells
(Homo sapiens)
ZIP6 and ZIP14 mediate zinc influx into cells
(Homo sapiens)
ZIP7 mediates zinc efflux from the endoplasmic reticulum
(Homo sapiens)
ZIP8 mediates zinc influx into cells
(Homo sapiens)
hZIP10 mediates zinc influx into cells
(Homo sapiens)
Participates
as an event of
Zinc transporters (Homo sapiens)
Event Information
Go Biological Process
zinc ion transmembrane transport (0071577)
Orthologous Events
Zinc influx into cells by the SLC39 gene family (Bos taurus)
Zinc influx into cells by the SLC39 gene family (Caenorhabditis elegans)
Zinc influx into cells by the SLC39 gene family (Canis familiaris)
Zinc influx into cells by the SLC39 gene family (Danio rerio)
Zinc influx into cells by the SLC39 gene family (Dictyostelium discoideum)
Zinc influx into cells by the SLC39 gene family (Drosophila melanogaster)
Zinc influx into cells by the SLC39 gene family (Gallus gallus)
Zinc influx into cells by the SLC39 gene family (Mus musculus)
Zinc influx into cells by the SLC39 gene family (Plasmodium falciparum)
Zinc influx into cells by the SLC39 gene family (Rattus norvegicus)
Zinc influx into cells by the SLC39 gene family (Saccharomyces cerevisiae)
Zinc influx into cells by the SLC39 gene family (Schizosaccharomyces pombe)
Zinc influx into cells by the SLC39 gene family (Sus scrofa)
Zinc influx into cells by the SLC39 gene family (Xenopus tropicalis)
Authored
Jassal, B (2009-09-25)
Reviewed
He, L (2009-11-12)
Created
Jassal, B (2009-09-25)
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