Reactome: A Curated Pathway Database

ZIP7 mediates zinc efflux from the endoplasmic reticulum

Stable Identifier
R-HSA-442393
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The human gene SLC39A7 encodes the zinc transporter ZIP7 (HKE4, Histidine-rich membrane protein Ke4). It is expressed in many tissues but especially in liver, kidney and the hormonal tissues apart from brain. Unlike the other members of the LZT subfamily, ZIP7 is localized to intracellular membranes of the ER rather than the plasma membrane and mediates zinc efflux into the cytoplasm (Taylor KM et al, 2004).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
zinc ion transmembrane transporter activity of SLC39A7 [endoplasmic reticulum membrane] SLC39A7 [endoplasmic reticulum membrane] zinc ion transmembrane transporter activity (0005385)
Orthologous Events
Cross References
Rhea