Reactome | ZIP7 mediates zinc efflux from the endoplasmic reticulum

ZIP7 mediates zinc efflux from the endoplasmic reticulum

Stable Identifier

R-HSA-442393

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

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Transport of small molecules (Homo sapiens)

- SLC-mediated transmembrane transport (Homo sapiens)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
    - Metal ion SLC transporters (Homo sapiens)
      - Zinc transporters (Homo sapiens)
        
        Zinc influx into cells by the SLC39 gene family (Homo sapiens)
        
        ZIP7 mediates zinc efflux from the endoplasmic reticulum (Homo sapiens)

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ZIP7 mediates zinc efflux from the endoplasmic reticulum

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The human gene SLC39A7 encodes the zinc transporter ZIP7 (HKE4, Histidine-rich membrane protein Ke4). It is expressed in many tissues but especially in liver, kidney and the hormonal tissues apart from brain. Unlike the other members of the LZT subfamily, ZIP7 is localized to intracellular membranes of the ER rather than the plasma membrane and mediates zinc efflux into the cytoplasm (Taylor KM et al, 2004).

Literature References

PubMed ID	Title	Journal	Year
14525538	Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters Morgan, HE, Taylor, KM, Nicholson, RI, Johnson, A	Biochem J	2004