ZIP7 mediates zinc efflux from the endoplasmic reticulum

Stable Identifier
R-HSA-442393
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The human gene SLC39A7 encodes the zinc transporter ZIP7 (HKE4, Histidine-rich membrane protein Ke4). It is expressed in many tissues but especially in liver, kidney and the hormonal tissues apart from brain. Unlike the other members of the LZT subfamily, ZIP7 is localized to intracellular membranes of the ER rather than the plasma membrane and mediates zinc efflux into the cytoplasm (Taylor KM et al, 2004).

Literature References
PubMed ID Title Journal Year
14525538 Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters

Taylor, KM, Morgan, HE, Johnson, A, Nicholson, RI

Biochem J 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
zinc ion transmembrane transporter activity of SLC39A7 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created