Reactome | HDAC3 [nucleoplasm]

HDAC3 [nucleoplasm]

Stable Identifier

R-HSA-442464

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone deacetylase 3, HDAC3_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P43356 MAGA2

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - RUNX2 regulates bone development (Homo sapiens)
        
        RUNX2 regulates osteoblast differentiation (Homo sapiens)
        
        RUNX2 binds ZNF521 and HDAC3 (Homo sapiens)
        
        HDAC3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15379 HDAC3

Gene Names

HDAC3

Chain

chain:1-428

Reference Genes

BioGPS Gene:8841 HDAC3

COSMIC (genes):HDAC3 HDAC3

CTD Gene:8841 HDAC3

dbSNP Gene:8841 HDAC3

ENSEMBL:ENSG00000171720 HDAC3

HGNC:4854 HDAC3

KEGG:hsa:8841 HDAC3

Monarch:8841 HDAC3

NCBI Gene:8841 HDAC3

OMIM:605166 HDAC3

UCSC:O15379 HDAC3

Reference Transcript

RefSeq:NM_003883.3 HDAC3

Other Identifiers

11718151_a_at

17000900

216326_PM_s_at

216326_s_at

2878727

2878728

2878729

2878730

2878733

2878734

2878735

2878736

2878737

2878738

2878739

2878740

2878741

2878742

2878743

2878744

2878745

2878746

2878747

2878748

2878749

2878750

2878751

2878752

2878753

2878754

2878755

2878756

2878757

2878759

2878760

2878761

2878762

2878763

2878764

2878765

2878766

2878767

2878768

35821_at

69667_at

8114691

8841

A_23_P7388

A_33_P3309929

GE62802

GO:0000118

GO:0000122

GO:0000132

GO:0000785

GO:0001222

GO:0001701

GO:0001934

GO:0003677

GO:0003682

GO:0003714

GO:0003824

GO:0004407

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006366

GO:0006476

GO:0007010

GO:0007346

GO:0008544

GO:0010467

GO:0016787

GO:0017053

GO:0019899

GO:0030332

GO:0031398

GO:0031490

GO:0031647

GO:0032008

GO:0032922

GO:0033558

GO:0040014

GO:0040029

GO:0042307

GO:0042752

GO:0042826

GO:0043066

GO:0043226

GO:0045892

GO:0045944

GO:0046329

GO:0048511

GO:0048856

GO:0051059

GO:0051225

GO:0060090

GO:0060816

GO:0061024

GO:0061351

GO:0061436

GO:0071498

GO:0072686

GO:0120162

GO:0140096

GO:0140110

GO:0140297

GO:0140861

GO:0160008

GO:0160009

GO:0160010

GO:1903575

GO:2000726

HMNXSV003010677

HMNXSV003041162

Hs.279789.12.S1_3p_a_at

ILMN_1772455

PH_hs_0024476

TC05001871.hg

TC05003274.hg

Participates

as a component of

as an input of

as an output of

as a member of

Other forms of this molecule

Unfolded HDAC3 [cytosol]

Inferred To

Hdac3 [nucleoplasm] (Mus musculus)

Histone deacetylase 3 [nucleoplasm] (Rattus norvegicus)

HOS2 [nucleoplasm] (Saccharomyces cerevisiae)

hda-2 [nucleoplasm] (Caenorhabditis elegans)

phd1 [nucleoplasm] (Schizosaccharomyces pombe)

HDAC3 [nucleoplasm] (Bos taurus)

HDAC3 [nucleoplasm] (Canis familiaris)

HDAC3 [nucleoplasm] (Dictyostelium discoideum)

HDAC3 [nucleoplasm] (Drosophila melanogaster)

HDAC3 [nucleoplasm] (Gallus gallus)

HDAC3 [nucleoplasm] (Sus scrofa)

hdac3 [nucleoplasm] (Danio rerio)

hdac3 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_003874.2

ZINC - World Drugs

HDAC3_HUMAN

Guide to Pharmacology - Targets

2617

OpenTargets

ENSG00000171720

ENSEMBL

ENST00000305264, ENSP00000302967

ZINC - FDA approved

HDAC3_HUMAN

ZINC - Substances

HDAC3_HUMAN

ZINC - Biogenic

HDAC3_HUMAN

ZINC target

O15379

PRO

O15379

GlyGen

O15379

PDB

4A69

ZINC - Investigational

HDAC3_HUMAN

ZINC - Metabolites

HDAC3_HUMAN

HPA

ENSG00000171720-HDAC3

Pharos - Targets

O15379

ZINC - Predictions - Purchasable

HDAC3_HUMAN

HMDB Protein

HMDBP09108

Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y618 NCOR2	2	NCOR2 [nucleoplasm] (R-HSA-442469) monoSUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904)	0.954	14
UniProt:Q13227 GPS2	1	GPS2 [nucleoplasm] (R-HSA-351642)	0.864	9
UniProt:O75376 NCOR1	2	NCOR1 [cytosol] (R-HSA-1253310) NCOR1 [nucleoplasm] (R-HSA-442501)	0.802	6
UniProt:O60907 TBL1X	1	TBL1X [nucleoplasm] (R-HSA-351644)	0.758	6
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.649	4
UniProt:O43823 AKAP8			0.649	10
UniProt:Q969R5 L3MBTL2	2	L3MBTL2 [nucleoplasm] (R-HSA-6804477) polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480)	0.645	6
UniProt:Q9BZK7 TBL1XR1	1	TBL1XR1 [nucleoplasm] (R-HSA-351643)	0.643	4
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.612	5
UniProt:P43356 MAGA2			0.591	4
UniProt:Q60974 Ncor1	3	Ncor1 [cytosol] (R-MMU-1253324) Ncor1 [nucleoplasm] (R-MMU-442459) Ncor1 [nucleoplasm] (R-MMU-442501)	0.589	2
UniProt:Q9UIS9 MBD1	2	MBD1 [nucleoplasm] (R-HSA-417134) monoSUMO1-K499,K538-MBD1 [nucleoplasm] (R-HSA-4090331)	0.576	3
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [cytosol] (R-HSA-75813) p-T286-CCND1 [nucleoplasm] (R-HSA-75811)	0.544	3
UniProt:P00558-1 PGK1			0.544	3
UniProt:P56524 HDAC4	3	polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) HDAC4 [nucleoplasm] (R-HSA-351581)	0.527	2
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.527	4
UniProt:Q9UKL0 RCOR1	1	RCOR1 [nucleoplasm] (R-HSA-996766)	0.527	2
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.527	4
UniProt:P51608 MECP2			0.527	3
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.527	2
UniProt:P78371 CCT2	3	CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [extracellular region] (R-HSA-6806220) CCT2 [cytosol] (R-HSA-390464)	0.527	4
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.524	2
UniProt:P60510 PPP4C	1	PPP4C [nucleoplasm] (R-HSA-5687750)	0.524	2
UniProt:P08393 ICP0			0.524	3
UniProt:P00558 PGK1	1	PGK1 [cytosol] (R-HSA-70483)	0.524	2
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.524	7
UniProt:Q92766 RREB1			0.512	3
UniProt:P48552 NRIP1	2	NRIP1 [nucleoplasm] (R-HSA-4086031) monoSUMO1-K756,K1154-NRIP1 [nucleoplasm] (R-HSA-4086057)	0.508	2
UniProt:Q15466 NR0B2	1	NR0B2 [nucleoplasm] (R-HSA-376312)	0.499	2
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.499	2
UniProt:P12504 VIF			0.499	2
UniProt:Q15022 SUZ12	2	SUZ12 [nucleoplasm] (R-HSA-212217) monoSUMO1-K75-SUZ12 [nucleoplasm] (R-HSA-4615932)	0.499	7
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.483	2
UniProt:P12755 SKI	1	SKI [nucleoplasm] (R-HSA-173473)	0.462	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.462	6

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