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HELZ2 [nucleoplasm]
Stable Identifier
R-HSA-442499
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
PRIC285, Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein, PR285_HUMAN
Locations in the PathwayBrowser
Expand all
Circadian Clock (Homo sapiens)
BMAL1:CLOCK,NPAS2 activates circadian gene expression (Homo sapiens)
Expression of PPARA (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of NPAS2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
RORA activates gene expression (Homo sapiens)
Expression of CPT1A (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of ANGPTL4 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of Adiponectin (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of CEBPA (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of FABP4 (aP2) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of Leptin (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of Lipoprotein lipase (LPL) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of Perilipin (PLIN) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
PPARG:RXRA heterodimer binds to fatty acid-like ligands (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (Homo sapiens)
Fatty acid ligands activate PPARA (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of ABCA1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of ABCB4 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of ACADM (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of ACOX1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of ACSL1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of AGT (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of ALAS1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of ANGPTL4 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of ANKRD1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of APOA1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of APOA2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of APOA5 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of CPT1A (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of CPT2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of CYP1A1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of CYP4A11 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of CYP7A1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of FABP1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of FADS1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of FATP1 (SLC27A1) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of FHL2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of G0S2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of GLIPR1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of GRHL1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of HMGCS2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of ME1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of NPAS2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of PEX11A (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of PLIN2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of PPARA (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of RGL1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of SULT2A1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of TIAM2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of TNFRSF21 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of TRIB3 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of TXNRD1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of UGT1A9 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Organelle biogenesis and maintenance (Homo sapiens)
Mitochondrial biogenesis (Homo sapiens)
Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
Expression of ALAS1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BYK8 HELZ2
Gene Names
HELZ2, KIAA1769, PRIC285
Chain
chain:1-2649
Reference Genes
BioGPS Gene:85441 HELZ2
CTD Gene:85441 HELZ2
dbSNP Gene:85441 HELZ2
ENSEMBL:ENSG00000130589 HELZ2
ENSEMBL_homo_sapiens_GENE:ENSG00000130589 HELZ2
HGNC:30021 HELZ2
KEGG Gene (Homo sapiens):85441 HELZ2
Monarch:85441 HELZ2
NCBI Gene:85441 HELZ2
OMIM:611265 HELZ2
UCSC:Q9BYK8 HELZ2
Reference Transcript
RefSeq:NM_033405.3 HELZ2
RefSeq:NM_001037335.2 HELZ2
Other Identifiers
0004200184
0104810050
11726803_x_at
11726804_a_at
16921289
228230_at
232517_3p_s_at
232517_s_at
232518_at
3913962
3913963
3913964
3913965
3913967
3913968
3913969
3913970
3913971
3913972
3913973
3913974
3913975
3913976
3913977
3913979
3913980
3913981
3913982
3913983
3913984
3913985
3913986
3913987
3913988
3913989
3913990
3913991
3913992
3913993
3913994
3913996
3913997
3913999
3914000
3914001
3914003
3914004
3914005
47899_at
51267
8067680
85441
A_24_P79199
A_33_P3400374
AAM74197
AB051556
AB201715
AF517673
AK055611
AK074171
AL121829
BAB21860
BAB70969
BAB84997
BAE46995
CCDS13527
CCDS33508
ENSG00000130589
ENSP00000393257
ENSP00000417401
ENST00000427522
ENST00000467148
EntrezGene:85441
GE482350
GO:0000166
GO:0000184
GO:0000988
GO:0003674
GO:0003677
GO:0003723
GO:0004004
GO:0004386
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0006629
GO:0008150
GO:0009056
GO:0009058
GO:0016020
GO:0016787
GO:0016887
GO:0019216
GO:0030374
GO:0034641
GO:0034655
GO:0043167
GO:0043226
GO:0045944
GO:0046872
HELZ2
HELZ2-202
HELZ2-204
HGNC:30021
HPA051267
Hs.151714.0.S1_3p_at
Hs.302647.0.S1_3p_s_at
ILMN_1787509
IPR012340
IPR022966
IPR027417
IPR031191
IPR036236
MIM:611265
NM_001037335
NM_033405
NP_001032412
NP_208384
PF00773
PF13086
PF13087
PH_hs_0009142
SM00955
TC20001035.hg
uc002yfl.2
uc061ynp.1
UPI0000246BF7
UPI000036706B
Participant Of
hasMember
Coactivators of PPARalpha [nucleoplasm]
input
PPARG:RXRA heterodimer binds to fatty acid-like ligands
hasComponent
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm]
Inferred To
Homologues of HELZ2 [nucleoplasm] (Danio rerio)
Homologues of HELZ2 [nucleoplasm] (Drosophila melanogaster)
Homologues of HELZ2 [nucleoplasm] (Xenopus tropicalis)
HELZ2 [nucleoplasm] (Canis familiaris)
HELZ2 [nucleoplasm] (Danio rerio)
HELZ2 [nucleoplasm] (Drosophila melanogaster)
HELZ2 [nucleoplasm] (Gallus gallus)
HELZ2 [nucleoplasm] (Mus musculus)
HELZ2 [nucleoplasm] (Rattus norvegicus)
HELZ2 [nucleoplasm] (Sus scrofa)
HELZ2 [nucleoplasm] (Taeniopygia guttata)
HELZ2 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_208384.3
,
NP_001032412.2
OpenTargets
ENSG00000130589
GeneCards
Q9BYK8
PRO
Q9BYK8
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