Reactome | HELZ2 [nucleoplasm]

HELZ2 [nucleoplasm]

Stable Identifier

R-HSA-442499

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PRIC285, Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein, PR285_HUMAN

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
    - Expression of ALAS1 (Homo sapiens)
      - PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
        
        Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
        
        HELZ2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BYK8 HELZ2

Gene Names

HELZ2, KIAA1769, PRIC285

Chain

chain:1-2896

Reference Genes

BioGPS Gene:85441 HELZ2

COSMIC (genes):HELZ2 HELZ2

CTD Gene:85441 HELZ2

dbSNP Gene:85441 HELZ2

ENSEMBL:ENSG00000130589 HELZ2

ENSEMBL_homo_sapiens_GENE:ENSG00000130589.16 HELZ2

HGNC:30021 HELZ2

KEGG Gene (Homo sapiens):85441 HELZ2

Monarch:85441 HELZ2

NCBI Gene:85441 HELZ2

OMIM:611265 HELZ2

UCSC:Q9BYK8 HELZ2

Reference Transcript

Other Identifiers

11726803_x_at

11726804_a_at

16921289

228230_PM_at

228230_at

232517_3p_s_at

232517_PM_s_at

232517_s_at

232518_at

3913961

3913962

3913963

3913964

3913965

3913967

3913968

3913969

3913970

3913971

3913972

3913973

3913974

3913975

3913976

3913977

3913979

3913980

3913981

3913982

3913983

3913984

3913985

3913986

3913987

3913988

3913989

3913990

3913991

3913992

3913993

3913994

3913995

3913996

3913997

3913999

3914000

3914001

3914003

3914004

3914005

3914006

3914007

3914008

3914009

3914010

3914011

3914012

3914013

47899_at

8067680

85441

85819_at

A_24_P79199

A_33_P3250851

A_33_P3400374

GE482350

GO:0000166

GO:0003677

GO:0003723

GO:0003724

GO:0003824

GO:0004386

GO:0004540

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0008859

GO:0016020

GO:0016787

GO:0030374

GO:0031047

GO:0035194

GO:0043186

GO:0043226

GO:0045944

GO:0046872

GO:0140098

GO:0140110

GO:0140657

HMNXSV003052766

Hs.151714.0.S1_3p_at

Hs.302647.0.S1_3p_s_at

ILMN_1787509

PH_hs_0009142

TC20001035.hg

Participates

as an input of

PPARG:RXRA heterodimer binds to fatty acid-like ligands (Homo sapiens)

as a component of

PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)

as a member of

Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)

Inferred To

Setx [nucleoplasm] (Drosophila melanogaster)

Homologues of HELZ2 [nucleoplasm] (Drosophila melanogaster)

HELZ2 [nucleoplasm] (Danio rerio)

HELZ2 [nucleoplasm] (Drosophila melanogaster)

HELZ2 [nucleoplasm] (Gallus gallus)

HELZ2 [nucleoplasm] (Mus musculus)

HELZ2 [nucleoplasm] (Sus scrofa)

upf1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001032412.2, NP_208384.3

OpenTargets

ENSG00000130589

GeneCards

Q9BYK8

HPA

ENSG00000130589-HELZ2

Ensembl

ENSP00000417401, ENSP00000393257, ENST00000427522, ENSG00000130589, ENST00000467148

PRO

Q9BYK8

Pharos - Targets

Q9BYK8

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