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HELZ2 [nucleoplasm]
Stable Identifier
R-HSA-442499
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
PRIC285, Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein, PR285_HUMAN
Locations in the PathwayBrowser
Expand all
Circadian Clock (Homo sapiens)
BMAL1:CLOCK,NPAS2 activates circadian gene expression (Homo sapiens)
Expression of PPARA (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of NPAS2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
RORA activates gene expression (Homo sapiens)
Expression of CPT1A (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of ANGPTL4 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of Adiponectin (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of CEBPA (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of FABP4 (aP2) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of Leptin (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of Lipoprotein lipase (LPL) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of Perilipin (PLIN) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
PPARG:RXRA heterodimer binds to fatty acid-like ligands (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
Fatty acid ligands activate PPARA (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of ABCA1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of ABCB4 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of ACADM (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of ACOX1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of ACSL1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of AGT (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of ALAS1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of ANGPTL4 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of ANKRD1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of APOA1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of APOA2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of APOA5 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of CPT1A (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of CPT2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of CYP1A1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of CYP4A11 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of CYP7A1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of FABP1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of FADS1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of FATP1 (SLC27A1) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of FHL2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of G0S2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of GLIPR1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of GRHL1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of HMGCS2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of ME1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of NPAS2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of PEX11A (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of PLIN2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of PPARA (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of RGL1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of SULT2A1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of TIAM2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of TNFRSF21 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of TRIB3 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of TXNRD1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Expression of UGT1A9 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
Organelle biogenesis and maintenance (Homo sapiens)
Mitochondrial biogenesis (Homo sapiens)
Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
Expression of ALAS1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
HELZ2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BYK8 HELZ2
Gene Names
HELZ2, KIAA1769, PRIC285
Chain
chain:1-2649
Reference Genes
BioGPS Gene:85441 HELZ2
COSMIC (genes):HELZ2 HELZ2
CTD Gene:85441 HELZ2
dbSNP Gene:85441 HELZ2
ENSEMBL:ENSG00000130589 HELZ2
HGNC:30021 HELZ2
KEGG Gene (Homo sapiens):85441 HELZ2
Monarch:85441 HELZ2
NCBI Gene:85441 HELZ2
OMIM:611265 HELZ2
UCSC:Q9BYK8 HELZ2
Reference Transcript
RefSeq:NM_001037335.2 HELZ2
RefSeq:NM_033405.3 HELZ2
Other Identifiers
0004200184
0104810050
11726803_x_at
11726804_a_at
16921289
228230_at
232517_3p_s_at
232517_s_at
232518_at
3913961
3913962
3913963
3913964
3913965
3913967
3913968
3913969
3913970
3913971
3913972
3913973
3913974
3913975
3913976
3913977
3913979
3913980
3913981
3913982
3913983
3913984
3913985
3913986
3913987
3913988
3913989
3913990
3913991
3913992
3913993
3913994
3913995
3913996
3913997
3913999
3914000
3914001
3914003
3914004
3914005
3914006
47899_at
8067680
85441
A_24_P79199
A_33_P3400374
GE482350
GO:0000166
GO:0000184
GO:0003674
GO:0003677
GO:0003723
GO:0003724
GO:0004386
GO:0004518
GO:0004540
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0006629
GO:0008150
GO:0009056
GO:0009058
GO:0016020
GO:0016787
GO:0016887
GO:0019216
GO:0030374
GO:0034641
GO:0034655
GO:0043167
GO:0043226
GO:0045944
GO:0046872
GO:0090501
Hs.151714.0.S1_3p_at
Hs.302647.0.S1_3p_s_at
ILMN_1787509
PH_hs_0009142
TC20001035.hg
Participant Of
input
PPARG:RXRA heterodimer binds to fatty acid-like ligands
hasComponent
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm]
hasMember
Coactivators of PPARalpha [nucleoplasm]
Inferred To
HELZ2 [nucleoplasm] (Canis familiaris)
HELZ2 [nucleoplasm] (Sus scrofa)
Helz2 [nucleoplasm] (Mus musculus)
Upf1 [nucleoplasm] (Drosophila melanogaster)
Cross References
RefSeq
NP_001032412.2
,
NP_208384.3
OpenTargets
ENSG00000130589
HPA
ENSG00000130589-HELZ2
GeneCards
Q9BYK8
Ensembl
ENSP00000393257
,
ENST00000467148
,
ENSG00000130589
,
ENST00000427522
,
ENSP00000417401
PRO
Q9BYK8
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