Reactome | BAIAP2 [cytosol]

BAIAP2 [cytosol]

Stable Identifier

R-HSA-442574

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IRSp53/58, Brain-specific angiogenesis inhibitor 1-associated protein 2, BAIP2_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O00401

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External Reference Information

External Reference

UniProt:Q9UQB8 BAIAP2

Gene Names

BAIAP2

Chain

chain:1-552

Reference Genes

BioGPS Gene:10458 BAIAP2

COSMIC (genes):BAIAP2 BAIAP2

CTD Gene:10458 BAIAP2

dbSNP Gene:10458 BAIAP2

ENSEMBL:ENSG00000175866 BAIAP2

HGNC:947 BAIAP2

KEGG Gene (Homo sapiens):10458 BAIAP2

Monarch:10458 BAIAP2

NCBI Gene:10458 BAIAP2

OMIM:605475 BAIAP2

UCSC:Q9UQB8 BAIAP2

Reference Transcript

Other Identifiers

0001570332

0001570438

0003360647

0005220471

10458

11722718_a_at

11722719_s_at

11722720_at

11726574_a_at

11739607_a_at

11749800_a_at

11749801_x_at

11754668_x_at

11762496_x_at

11762757_a_at

11762758_x_at

16838750

205293_x_at

205294_at

207832_at

209502_s_at

3737698

3737699

3737700

3737717

3737720

3737730

3737732

3737733

3737741

3737744

3737745

3737746

3737747

3737749

3737750

3737751

3737753

3737754

3737755

3737756

3737758

3737763

3737764

3737765

3737766

37761_at

8010562

A_24_P159648

GE53407

GO:0000902

GO:0001221

GO:0001726

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005791

GO:0005794

GO:0005829

GO:0005856

GO:0005874

GO:0005886

GO:0005912

GO:0006810

GO:0007009

GO:0007010

GO:0007155

GO:0007165

GO:0007267

GO:0007409

GO:0007420

GO:0008022

GO:0008092

GO:0008093

GO:0008134

GO:0008150

GO:0008286

GO:0008360

GO:0009617

GO:0010976

GO:0014069

GO:0015629

GO:0016020

GO:0016192

GO:0016358

GO:0022607

GO:0030141

GO:0030154

GO:0030165

GO:0030175

GO:0030182

GO:0030674

GO:0030838

GO:0031410

GO:0032956

GO:0034330

GO:0035418

GO:0038096

GO:0042802

GO:0042995

GO:0043005

GO:0043025

GO:0043197

GO:0043198

GO:0043226

GO:0044306

GO:0048010

GO:0048167

GO:0048856

GO:0050804

GO:0050877

GO:0051017

GO:0051764

GO:0060076

GO:0061003

GO:0061024

GO:0061845

GO:0061846

GO:0065003

GO:0070062

GO:0070064

GO:0071364

GO:0097060

GO:0097110

GO:0098609

GO:0098641

GO:0098685

GO:0098793

GO:0098794

GO:0098978

GO:0099523

GO:0099524

GO:1905232

GO:2000251

GO:2000463

ILMN_1697905

ILMN_1699727

ILMN_1705922

ILMN_2258749

PH_hs_0022412

TC17000924.hg

g12803352_3p_a_at

g4239983_3p_s_at

g9257198_3p_at

Participant Of

input

RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)

hasComponent

Inferred To

IRSp53 [cytosol] (Drosophila melanogaster)

Ghost homologue of BAIAP2 [cytosol] (Caenorhabditis elegans)

Ghost homologue of BAIAP2 [cytosol] (Dictyostelium discoideum)

Baiap2 [cytosol] (Mus musculus)

Baiap2 [cytosol] (Rattus norvegicus)

baiap2a [cytosol] (Danio rerio)

BAIAP2 [cytosol] (Canis familiaris)

BAIAP2 [cytosol] (Gallus gallus)

BAIAP2 [cytosol] (Sus scrofa)

BAIAP2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_006331.1, NP_059345.1, XP_005257005.1, NP_059344.1, NP_001138360.1

OpenTargets

ENSG00000175866

HPA

ENSG00000175866-BAIAP2

GeneCards

Q9UQB8

Ensembl

ENSP00000458964, ENSG00000175866, ENSP00000413069, ENST00000575712, ENST00000321280, ENST00000321300, ENSP00000316338, ENST00000435091, ENSP00000315685, ENSP00000401022, ENST00000428708

PRO

Q9UQB8

HMDB Protein

HMDBP08316

PDB

1Y2O, 6BD2, 2YKT, 6BCR, 6BQT, 3RNJ, 1WDZ, 6BCY, 4JS0, 6BD1

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12929 EPS8			0.855	10
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.744	5
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.728	4
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.688	3
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.667	3
UniProt:Q08509 EPS8			0.639	8
UniProt:Q14678 KANK1	3	p-12Y KANK1(1-899)-PDGFRB(415-1106) fusion [plasma membrane] (R-HSA-9673890) KANK1 [nucleoplasm] (R-HSA-9018640) KANK1(1-899)-PDGFRB(415-1106) fusion [plasma membrane] (R-HSA-9673593)	0.639	6
UniProt:P54259 ATN1	1	ATN1 [nucleoplasm] (R-HSA-6807083)	0.635	3
UniProt:Q03173 Enah	2	Enah [cytosol] (R-MMU-426406) Enah [cytosol] (R-MMU-430212)	0.591	3
UniProt:Q9NZQ3 NCKIPSD	1	NCKIPSD [cytosol] (R-HSA-2197671)	0.573	2
UniProt:P60953 CDC42	3	CDC42 [cytosol] (R-HSA-442630) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [plasma membrane] (R-HSA-449545)	0.573	2
UniProt:Q9NZ81 PRR13			0.556	3
UniProt:Q9UFG5 CS025			0.556	3
UniProt:Q13625-3 TP53BP2			0.556	3
UniProt:Q15427 SF3B4	1	SF3B4 [nucleoplasm] (R-HSA-71975)	0.556	3
UniProt:O00401 WASL	4	N-WASP [cytosol] (R-HSA-201873) p-Y256-WASL [cytosol] (R-HSA-2197672) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.547	2
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.527	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.527	3
UniProt:Q8CFN2 Cdc42	3	Cdc42 [cytosol] (R-RNO-428464) Cdc42 [endoplasmic reticulum membrane] (R-RNO-5672086) Cdc42 [plasma membrane] (R-RNO-449545)	0.527	2
UniProt:Q7DB77 TIR			0.508	3
UniProt:P60953-2 CDC42			0.508	2

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