Reactome | CDC42 [cytosol]

CDC42 [cytosol]

Stable Identifier

R-HSA-442630

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cell division control protein 42 homolog, CDC42_HUMAN

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Parasite infection (Homo sapiens)
        
        Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        An unknown GEF exchanges GTP for GDP on CDC42:GDP (Homo sapiens)
        
        CDC42:GDP [cytosol] (Homo sapiens)
        
        CDC42 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P60953 CDC42

Gene Names

CDC42, cell division cycle 42

Chain

chain:1-188, propeptide:189-191

Reference Genes

BioGPS Gene:998 CDC42

COSMIC (genes):CDC42 CDC42

CTD Gene:998 CDC42

dbSNP Gene:998 CDC42

ENSEMBL:ENSG00000070831 CDC42

HGNC:1736 CDC42

KEGG:hsa:998 CDC42

Monarch:998 CDC42

NCBI Gene:998 CDC42

OMIM:116952 CDC42

UCSC:P60953 CDC42

Reference Transcript

Participates

as a candidate of

as a member of

RAC1, CDC42 [cytosol] (Homo sapiens)

as a component of

Other forms of this molecule

CDC42 [plasma membrane]

CDC42 [endoplasmic reticulum membrane]

Inferred To

CDC42 [cytosol] (Bos taurus)

CDC42 [cytosol] (Caenorhabditis elegans)

CDC42 [cytosol] (Canis familiaris)

CDC42 [cytosol] (Dictyostelium discoideum)

CDC42 [cytosol] (Drosophila melanogaster)

CDC42 [cytosol] (Gallus gallus)

CDC42 [cytosol] (Mus musculus)

CDC42 [cytosol] (Saccharomyces cerevisiae)

CDC42 [cytosol] (Schizosaccharomyces pombe)

CDC42 [cytosol] (Sus scrofa)

cdc42 [cytosol] (Danio rerio)

cdc42 [cytosol] (Xenopus tropicalis)

Cdc42 [cytosol] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000070831

ENSEMBL

ENST00000695800, ENSP00000341072, ENSP00000512225, ENSP00000398327, ENSP00000512182, ENSP00000512222, ENSP00000512180, ENST00000695802, ENST00000695860, ENST00000315554, ENSP00000314458, ENST00000662562, ENST00000695797, ENSP00000512178, ENSP00000512176, ENSP00000512177, ENSP00000512179, ENST00000695796, ENSP00000499457, ENSP00000383118, ENSG00000070831, ENST00000695857, ENSP00000499612, ENST00000411827, ENST00000695798, ENST00000695799, ENST00000656825, ENST00000344548, ENST00000400259

ZINC - Substances

CDC42_HUMAN

ZINC - Biogenic

CDC42_HUMAN

ZINC target

P60953

PRO

P60953

GlyGen

P60953

PDB

2WMO, 2WMN, 1KZG, 4YC7, 1E0A, 4DID, 2ODB, 1EES, 1CF4, 2DFK, 4ITR, 3GCG, 2NGR, 1AN0, 1A4R, 4JS0, 6AJL, 3VHL, 3QBV, 5UPL, 6SIU, 1KI1, 2KB0, 1DOA, 2WM9, 5CJP, 6TKY, 8I5F, 6TKZ, 6SUP, 1AM4, 1GRN, 1CEE, 5FI1, 6AJ4, 5UPK, 1KZ7, 1GZS, 1AJE, 2QRZ, 7S0Y, 4YDH, 5HZK, 2ASE, 1NF3

IntEnz

3.6.5.2

GeneCards

CDC42

HPA

ENSG00000070831-CDC42

Pharos - Targets

P60953

Orphanet

CDC42

ZINC - Predictions - Purchasable

CDC42_HUMAN

HMDB Protein

HMDBP01784

Interactors (52)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.957	19
UniProt:P42768 WAS	2	WAS [cytosol] (R-HSA-201879) p-Y291-WAS [cytosol] (R-HSA-2197668)	0.949	14
UniProt:Q13153 PAK1	5	p-S144,T423-PAK1 [cytosol] (R-HSA-399819) PAK1 [cytosol] (R-HSA-162629) Active PAK1 [cytosol] (R-HSA-8964622) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) PAK1 [plasma membrane] (R-HSA-3928409)	0.944	15
UniProt:Q9BYG5 PARD6B	2	PARD6B [plasma membrane] (R-HSA-418193) PARD6B [cytosol] (R-HSA-419973)	0.896	18
UniProt:Q00587 CDC42EP1	1	CDC42EP1 [cytosol] (R-HSA-9691382)	0.886	9
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524)	0.874	9
UniProt:O14613 CDC42EP2	2	p-CDC42EP2 [cytosol] (R-HSA-5692662) CDC42EP2 [cytosol] (R-HSA-5692692)	0.83	10
UniProt:O96013 PAK4	1	PAK4 [cytosol] (R-HSA-428461)	0.825	5
UniProt:Q5VT25 CDC42BPA	1	CDC42BPA [cytosol] (R-HSA-419871)	0.815	6
GTP [ChEBI:15996]	7	GTP [cilium] (R-ALL-5617813) GTP [early endosome membrane] (R-ALL-2130170) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221)	0.797	8
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.794	10
UniProt:P52565 ARHGDIA	1	ARHGDIA [cytosol] (R-HSA-194478)	0.756	5
UniProt:Q9NPB6 PARD6A	4	PARD6A [plasma membrane] (R-HSA-418187) PARD6A [cytosol] (R-HSA-420001) PARD6A [cell junction] (R-HSA-2134480) p-S345-PARD6A [plasma membrane] (R-HSA-2134533)	0.755	7
UniProt:O00401 WASL	4	N-WASP [cytosol] (R-HSA-201873) p-Y256-WASL [cytosol] (R-HSA-2197672) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.75	4
UniProt:Q9P286 PAK5	2	PAK5 [cytosol] (R-HSA-428459) PAK7 [plasma membrane] (R-HSA-211555)	0.743	5
UniProt:Q9JK83	2	Pard6b [plasma membrane] (R-MMU-418193) Pard6b [cytosol] (R-MMU-419973)	0.729	6
UniProt:Q9NRR3 CDC42SE2	1	CDC42SE2 [plasma membrane] (R-HSA-9714853)	0.725	5
UniProt:Q13576 IQGAP2	3	IQGAP2 [cytosol] (R-HSA-5625975) IQGAP2 [plasma membrane] (R-HSA-6804811) IQGAP2 [secretory granule membrane] (R-HSA-6804779)	0.688	4
UniProt:Q9BYG4 PARD6G	2	PARD6G [plasma membrane] (R-HSA-418192) PARD6G [cytosol] (R-HSA-419967)	0.681	5
UniProt:P19878 NCF2	2	p-T233-NCF2 [phagolysosome] (R-HSA-1996211) NCF2 [cytosol] (R-HSA-1222600)	0.676	3
UniProt:P41743 PRKCI	3	PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [cytosol] (R-HSA-58206) PRKCI [plasma membrane] (R-HSA-420005)	0.67	5
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.668	9
UniProt:Q9UQB8-4 BAIAP2			0.667	4
UniProt:Q9NQU5 PAK6	1	PAK6 [cytosol] (R-HSA-428454)	0.659	4
UniProt:Q9NRR8 C42S1			0.659	3
UniProt:Q61036 Pak3	3	phospho-p-S154,T436-PAK3 [plasma membrane] (R-MMU-3928479) phospho-p-S154,T436-PAK3 [cytosol] (R-MMU-5357471) Pak3 [cytosol] (R-MMU-442833)	0.656	3
UniProt:Q86VI3 IQGAP3	1	IQGAP3 [cytosol] (R-HSA-5625977)	0.643	5
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.621	3
UniProt:Q92963 RIT1	1	RIT1 [plasma membrane] (R-HSA-187703)	0.619	6
UniProt:Q15642 TRIP10	1	TRIP10 [cytosol] (R-HSA-195120)	0.609	2
UniProt:O30916 SOPB			0.602	5
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.573	2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.564	2
UniProt:O52623 SOPE			0.558	2
UniProt:Q00587-2 CDC42EP1			0.556	3
UniProt:Q8WUI4-6 HDAC7			0.556	3
UniProt:B2RTY4 MYO9A	1	MYO9A [cytosol] (R-HSA-200628)	0.553	2
UniProt:Q9Y5S2 CDC42BPB	1	CDC42BPB [cytosol] (R-HSA-419873)	0.547	2
UniProt:P52306 RAP1GDS1	1	RAP1GDS1 [mitochondrial outer membrane] (R-HSA-9693756)	0.547	2
UniProt:Q9H3Q1 CDC42EP4	1	CDC42EP4 [cytosol] (R-HSA-9691381)	0.547	2
UniProt:P35268 RPL22	1	RPL22 [cytosol] (R-HSA-72428)	0.547	2
UniProt:Q16584 MAP3K11	1	MAP3K11 [cytosol] (R-HSA-449607)	0.536	3
UniProt:Q9VEX9	1	Bin1 [nucleoplasm] (R-DME-351694)	0.527	2
UniProt:P60660 MYL6	2	p-S20-MYL6 [cytosol] (R-HSA-445778) MYL6 [cytosol] (R-HSA-419186)	0.527	2
UniProt:Q9UHB6 LIMA1			0.527	2
UniProt:O15511 ARPC5	4	ARPC5 [secretory granule lumen] (R-HSA-6801071) ARPC5 [extracellular region] (R-HSA-6806476) ARPC5 [ficolin-1-rich granule lumen] (R-HSA-6801065) ARPC5 [cytosol] (R-HSA-200806)	0.527	2
UniProt:O08816 Wasl	1	N-Wasp [cytosol] (R-RNO-442543)	0.524	2
UniProt:P60953 CDC42	3	CDC42 [plasma membrane] (R-HSA-449545) CDC42 [cytosol] (R-HSA-442630) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086)	0.524	2
UniProt:O95477 ABCA1	11	ABCA1 [plasma membrane] (R-HSA-194209) 4xPALM-C-p-2S-ABCA1 [plasma membrane] (R-HSA-5682069) 4xPALM-C-ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682085) 4xPALM-C-ABCA1 [plasma membrane] (R-HSA-5682091) ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682105) ABCA1 Q537R [plasma membrane] (R-HSA-5682199) ABCA1 R587W [plasma membrane] (R-HSA-5682197) ABCA1 S1446L [plasma membrane] (R-HSA-5682195) ABCA1 C1417R [plasma membrane] (R-HSA-5682190) ABCA1 N935S [plasma membrane] (R-HSA-5682200) ABCA1 W590S [plasma membrane] (R-HSA-5682201)	0.524	2
UniProt:Q96L34 MARK4	1	MARK4 [cytosol] (R-HSA-5626653)	0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	11
UniProt:P45983 MAPK8	3	p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) MAPK8 [cytosol] (R-HSA-168141)	0.483	2

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