CREB1 phosphorylation through the activation of Adenylate Cyclase

Stable Identifier
R-HSA-442720
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane, cytosol, nucleoplasm
ReviewStatus
5/5
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CREB1 phosphorylation through the activation of Adenylate Cyclase
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Ca2+ influx through activated NMDA receptors in the post synaptic neurons activates adenylate cyclase-mediated signal transduction, leading to the activation of PKA and phosphorylation and activation of CREB1 induced transcription (Masada et al. 2012, Chetkovich et al. 1991, Chetkovich and Sweatt 1993
Literature References
PubMed ID Title Journal Year
19244110 RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway

Vikis, HG, Lu, Y, Liu, Y, You, M, James, MA

Cancer Res 2009
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Events
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Event Information
Go Biological Process
chemical synaptic transmission (0007268)
Orthologous Events
CREB1 phosphorylation through the activation of Adenylate Cyclase (Bos taurus)
CREB1 phosphorylation through the activation of Adenylate Cyclase (Caenorhabditis elegans)
CREB1 phosphorylation through the activation of Adenylate Cyclase (Canis familiaris)
CREB1 phosphorylation through the activation of Adenylate Cyclase (Danio rerio)
CREB1 phosphorylation through the activation of Adenylate Cyclase (Drosophila melanogaster)
CREB1 phosphorylation through the activation of Adenylate Cyclase (Gallus gallus)
CREB1 phosphorylation through the activation of Adenylate Cyclase (Mus musculus)
CREB1 phosphorylation through the activation of Adenylate Cyclase (Rattus norvegicus)
CREB1 phosphorylation through the activation of Adenylate Cyclase (Saccharomyces cerevisiae)
CREB1 phosphorylation through the activation of Adenylate Cyclase (Schizosaccharomyces pombe)
CREB1 phosphorylation through the activation of Adenylate Cyclase (Sus scrofa)
CREB1 phosphorylation through the activation of Adenylate Cyclase (Xenopus tropicalis)
Authored
Mahajan, SS  (2009-10-29)
Reviewed
Tukey, D  (2009-11-18)
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Mahajan, SS  (2009-09-29)
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