Raf activation

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Raf is a downstream effector of ras. Raf is activated upon phosphorylation at S338, oligomerization and membrane localization. Membrane localization is facilitated by ras. Interaction of ras with raf is a necessary step but not sufficient for raf activation. Other unknown protein partner interactions are required for raf activation. Raf further activates MAP kinase.

Literature References
PubMed ID Title Journal Year
19727074 A dimerization-dependent mechanism drives RAF catalytic activation

Rajakulendran, T, Sahmi, M, Lefrancois, M, Sicheri, F, Therrien, M

Nature 2009
22592532 Calcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylates Raf-1 at serine 338 and mediates Ras-stimulated Raf-1 activation

Salzano, M, Rusciano, MR, Russo, E, Bifulco, M, Postiglione, L, Vitale, M

Cell Cycle 2012
17603483 Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy

Pandit, B, Sarkozy, A, Pennacchio, LA, Carta, C, Oishi, K, Martinelli, S, Pogna, EA, Schackwitz, W, Ustaszewska, A, Landstrom, A, Bos, JM, Ommen, SR, Esposito, G, Lepri, F, Faul, C, Mundel, P, López Siguero, JP, Tenconi, R, Selicorni, A, Rossi, C, Mazzanti, L, Torrente, I, Marino, B, Digilio, MC, Zampino, G, Ackerman, MJ, Dallapiccola, B, Tartaglia, M, Gelb, BD

Nat Genet 2007
12062470 MPP+ increases alpha-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells

Gómez-Santos, C, Ferrer, I, Reiriz, J, Viñals, F, Barrachina, M, Ambrosio, S

Brain Res 2002
17064357 Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease

Mei, M, Su, B, Harrison, K, Chao, M, Siedlak, SL, Previll, LA, Jackson, L, Cai, DX, Zhu, X

J Neurochem 2006
Participant Of
Catalyst Activity
Catalyst Activity
kinase activity of CaMKII [cytosol]
Physical Entity
Orthologous Events