Reactome: A Curated Pathway Database

Raf activation

Stable Identifier
R-HSA-442726
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Raf is a downstream effector of ras. Raf is activated upon phosphorylation at S338, oligomerization and membrane localization. Membrane localization is facilitated by ras. Interaction of ras with raf is a necessary step but not sufficient for raf activation. Other unknown protein partner interactions are required for raf activation. Raf further activates MAP kinase.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
kinase activity of CaMKII [cytosol] CaMKII [cytosol] kinase activity (0016301)
Orthologous Events