There will be a maintenance on OICR IT systems starting Friday Dec 15 at 6PM EST until midnight Sunday Dec 17; Reactome will be affected by this downtime

Service under maintenance from Friday Dec 15 at 6PM EST until midnight Sunday Dec 17

Raf activation

Stable Identifier
R-HSA-442726
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Raf is a downstream effector of ras. Raf is activated upon phosphorylation at S338, oligomerization and membrane localization. Membrane localization is facilitated by ras. Interaction of ras with raf is a necessary step but not sufficient for raf activation. Other unknown protein partner interactions are required for raf activation. Raf further activates MAP kinase.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
kinase activity of CaMKII [cytosol]
Physical Entity
Activity
Orthologous Events