Reactome | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde

CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde

Stable Identifier

R-HSA-442729

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane, cytosol, nucleoplasm

ReviewStatus

5/5

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CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde

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In addition to inducing long-term potentiation (LTP), NMDA receptor-mediated activation of CaMKII leads to transcriptional changes that are implicated in LTP maintenance (reviewed by Miyamoto 2006). CaMKII-gamma (CAMK2G) isoform is involved in nuclear shuttling of the calcium/calmodulin complex (CALM1:4xCa2+), which enables CaMKK-mediated activation of the nuclear calcium/calmodulin dependent kinase CaMKIV (CAMK4). Activated CaMKIV phosphorylates the transcription factor CREB1 and activates CREB1-mediated transcription (Ma et al. 2014, Cohen et al. 2018).

Literature References

PubMed ID	Title	Journal	Year
25303525	γCaMKII shuttles Ca²⁺/CaM to the nucleus to trigger CREB phosphorylation and gene expression Ma, H, Groth, RD, Cohen, SM, Emery, JF, Li, B, Hoedt, E, Zhang, G, Neubert, TA, Tsien, RW	Cell	2014
29934532	Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory Cohen, SM, Suutari, B, He, X, Wang, Y, Sanchez, S, Tirko, NN, Mandelberg, NJ, Mullins, C, Zhou, G, Wang, S, Kats, I, Salah, A, Tsien, RW, Ma, H	Nat Commun	2018
16799259	Molecular mechanism of neuronal plasticity: induction and maintenance of long-term potentiation in the hippocampus Miyamoto, E	J Pharmacol Sci	2006