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Activation of MAPK

Stable Identifier
R-HSA-442737
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MAPK/ERK is phosphorylated at threonine 185 and tyrosine 187 by membrane associated activated raf kianse leading to the activation of MAPK/ERK kinase. The activated MAPK/ERK in turn activates ribosomal S6 kinase.

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
kinase activity of p-S338-RAF1 [plasma membrane]
Physical Entity
Activity
Orthologous Events