Reactome: A Curated Pathway Database

Activation of MAPK

Stable Identifier
R-HSA-442737
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MAPK/ERK is phosphorylated at threonine 185 and tyrosine 187 by membrane associated activated raf kianse leading to the activation of MAPK/ERK kinase. The activated MAPK/ERK in turn activates ribosomal S6 kinase.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
kinase activity of p-S338-RAF1 [plasma membrane] p-S338-RAF1 [plasma membrane] kinase activity (0016301)
Orthologous Events