Activation of CaMKK

Stable Identifier
R-HSA-442749
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CaMKK is fully activated upon binding Ca2+/Calmodulin after intracellular Ca2+ levels increase. Once CaMKK binds Ca2+/Calmodulin it autophosphorylates, resulting in activation. CaMKK is negatively regulated by phosphorylation of S74 and T108 by PKA. Once activated CaMKK phosphorylates CaMKIV in a Ca2+/Calmodulin dependent manner.

Literature References
PubMed ID Title Journal Year
15591024 Calcium/calmodulin kinase IV pathway is involved in the transcriptional regulation of the corticotropin-releasing hormone gene promoter in neuronal cells

Yamamori, E, Asai, M, Yoshida, M, Takano, K, Itoi, K, Oiso, Y, Iwasaki, Y

J Mol Endocrinol 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
calmodulin-dependent protein kinase activity of CAMKK1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed