Activation of RasGRF

Stable Identifier
R-HSA-442760
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

After Ca2+ influx through the activated NMDA receptors, RASGRF1 homooligomers and heterooligomers with RASGRF2 are activated by binding to the Ca2+:Calmodulin complex (CALM1:4xCa2+) and by associating with the GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors through direct interaction between GluN2B and RASGRF1 (Anborgh et al. 1999, Krapivinsky et al. 2003).

Literature References
PubMed ID Title Journal Year
14622581 The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1

Krapivinsky, G, Krapivinsky, L, Manasian, Y, Ivanov, A, Tyzio, R, Pellegrino, C, Ben-Ari, Y, Clapham, DE, Medina, I

Neuron 2003
10373510 Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf

Anborgh, PH, Qian, X, Papageorge, AG, Vass, WC, DeClue, JE, Lowy, DR

Mol Cell Biol 1999
Participants
Participant Of
Inferred From
Authored
Reviewed
Created
Cite Us!