Ras activation upon Ca2+ influx through NMDA receptor

Stable Identifier
R-HSA-442982
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Ras activation upon Ca2+ influx through NMDA receptor
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Ca2+ influx through the NMDA receptor triggers RAS signaling through the activation of RAS guanyl nucleotide exchange factor RasGRF (Krapivinsky et al. 2003).
Literature References
PubMed ID Title Journal Year
14622581 The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1

Krapivinsky, G, Krapivinsky, L, Manasian, Y, Ivanov, A, Tyzio, R, Pellegrino, C, Ben-Ari, Y, Clapham, DE, Medina, I

Neuron 2003
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BioModels Database
Authored
Mahajan, SS  (2009-10-29)
Reviewed
Tukey, D  (2009-11-18)
Yi, F  (2018-11-02)
Hansen, KB  (2018-11-02)
Created
Mahajan, SS  (2009-09-29)
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