Reactome | SCN8A [plasma membrane]

SCN8A [plasma membrane]

Stable Identifier

R-HSA-443381

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Sodium channel protein type 8 subunit alpha, SCN8A_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - L1CAM interactions (Homo sapiens)
      - Interaction between L1 and Ankyrins (Homo sapiens)
        
        Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)
        
        KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNAs [plasma membrane] (Homo sapiens)
        
        SCN8A [plasma membrane] (Homo sapiens)
        
        NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin:KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNAs [plasma membrane] (Homo sapiens)
        
        SCN8A [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UQD0 SCN8A

Gene Names

SCN8A, MED

Chain

chain:1-1980

Reference Genes

BioGPS Gene:6334 SCN8A

COSMIC (genes):SCN8A SCN8A

CTD Gene:6334 SCN8A

dbSNP Gene:6334 SCN8A

ENSEMBL:ENSG00000196876 SCN8A

ENSEMBL_homo_sapiens_GENE:ENSG00000196876.19 SCN8A

HGNC:10596 SCN8A

KEGG Gene (Homo sapiens):6334 SCN8A

Monarch:6334 SCN8A

NCBI Gene:6334 SCN8A

OMIM:600702 SCN8A

UCSC:Q9UQD0 SCN8A

Reference Transcript

Other Identifiers

11740074_s_at

11751898_a_at

16751319

17117567

207049_PM_at

207049_at

235969_PM_at

235969_at

236329_PM_at

236329_at

236479_PM_at

236479_at

237790_PM_at

237790_at

244708_PM_at

244708_at

3414970

3414971

3414976

3414977

3414982

3414983

3414986

3414987

3414988

3414990

3414992

3414993

3414994

3414996

3414998

3414999

3415000

3415001

3415002

3415003

3415004

3415005

3415006

3415008

3415009

3415010

3415011

3415012

3415014

3415017

3415019

3415020

3415021

3415024

3415025

3415026

3415027

3415028

3415047

3415048

3415049

3415051

3415053

3415055

35510_at

44389_at

45449_at

55796_at

60085_at

6334

7955502

7955533

79605_at

A_14_P103419

A_23_P433504

A_23_P76245

A_24_P231026

A_32_P188143

A_33_P3408962

GE57456

GE80487

GO:0000166

GO:0001518

GO:0005215

GO:0005216

GO:0005248

GO:0005261

GO:0005272

GO:0005515

GO:0005524

GO:0005886

GO:0005891

GO:0006811

GO:0006814

GO:0007399

GO:0007422

GO:0008331

GO:0016020

GO:0019228

GO:0021554

GO:0030018

GO:0030054

GO:0030424

GO:0031402

GO:0031410

GO:0033268

GO:0034220

GO:0034702

GO:0035725

GO:0042552

GO:0042995

GO:0043194

GO:0043226

GO:0048787

GO:0048856

GO:0050877

GO:0055085

GO:0098688

GO:0098703

GO:0098839

GO:0098978

HMNXSV003006504

HMNXSV003017680

Hs.12778.0.A1_3p_at

Hs.195362.0.A1_3p_at

Hs.21558.0.A1_3p_at

Hs.24865.0.A1_3p_at

Hs.26299.0.A1_3p_at

Hs.26299.0.A1_3p_x_at

Hs2.407217.1.S1_3p_s_at

ILMN_1674795

ILMN_1781951

PH_hs_0006989

PH_hs_0025517

TC12000407.hg

TC12000408.hg

TC12002360.hg

g7657543_3p_at

Participates

as a candidate of

SCNAs [plasma membrane] (Homo sapiens)

Inferred To

SCN8A [plasma membrane] (Bos taurus)

Cross References

RefSeq

XP_006719619.1, NP_001317189.1, XP_016875283.1, NP_055006.1, NP_001171455.1, XP_011536953.1

Guide to Pharmacology - Targets

583

OpenTargets

ENSG00000196876

ZINC - Substances

SCN8A_HUMAN

ZINC target

Q9UQD0

ZINC - Biogenic

SCN8A_HUMAN

PRO

Q9UQD0

PDB

8FHD, 8GZ1, 8GZ2

HPA

ENSG00000196876-SCN8A

GeneCards

Q9UQD0

Ensembl

ENSP00000487583, ENSP00000347255, ENST00000662684, ENST00000355133, ENSP00000346534, ENST00000545061, ENSP00000476447, ENSP00000499636, ENSP00000440360, ENST00000627620, ENST00000599343, ENSG00000196876, ENST00000354534

Pharos - Targets

Q9UQD0

Orphanet

20890

ZINC - Predictions - Purchasable

SCN8A_HUMAN

HMDB Protein

HMDBP09088