Linkage of L1 with treadmilling F-actin

Stable Identifier
R-HSA-443779
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The COOH termini of all ERM proteins have sequence motifs that bind directly to F-actin. The L1 molecules on the cell surface are translocated to the C-domain by coupling with the retrograde F-actin. The force generated by linking L1 clusters with retrograde F-actin flow leads to the migration of the growth cone.

Literature References
PubMed ID Title Journal Year
18478542 Interactions between the L1 cell adhesion molecule and ezrin support traction-force generation and can be regulated by tyrosine phosphorylation

Sakurai, T, Gil, OD, Whittard, JD, Gazdoiu, M, Joseph, T, Wu, J, Waksman, A, Benson, DL, Salton, SR, Felsenfeld, DP

J Neurosci Res 2008
Participants
Participant Of
Orthologous Events
Authored
Reviewed