Linkage of L1 with treadmilling F-actin

Stable Identifier
R-HSA-443779
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The COOH termini of all ERM proteins have sequence motifs that bind directly to F-actin. The L1 molecules on the cell surface are translocated to the C-domain by coupling with the retrograde F-actin. The force generated by linking L1 clusters with retrograde F-actin flow leads to the migration of the growth cone.

Participants
Participant Of
Orthologous Events