Reactome: A Curated Pathway Database

Cis-heterodimerization of L1 and DM-GRASP/ALCAM/BEN

Stable Identifier
R-HSA-443780
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

DM GRASP/ALCAM/BEN is one of the heterodimerizing partners for L1/NgCAM. Interation between L1/NgCAM and DM GRASP in the growth cone membrane is involved in L1 stimulated neurite outgrowth. Trans binding of L1 on retinal growth cones to ALCAM on the superior colliculus potentiates adhesion, leading to correct synaptic targeting.

Participants
Participant Of
Inferred From