Interaction of NUMB with L1

Stable Identifier
R-HSA-443783
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Numb is thought to be a phosphotyrosine binding (PTB) domain containing cargo specific adaptor protein, which links specific cargo to the endocytic machinery. It associates with collapsin response mediator protein-2 (CRMP 2) with its PTB domain and alpha adaptin (a subunit of the AP 2 adaptor complex) through its tripeptide Asp-Pro-Phe (DPF) motif, and is involved in clathrin dependent endocytosis at the plasma membrane. Numb is associated with L1 under physiological conditions and functions in endocytosis of L1 in the C domain membrane of axonal growth cones.

Literature References
PubMed ID Title Journal Year
12942088 CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth Nat Cell Biol 2003
Participants
Participant Of
Orthologous Events