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EPHB2 [plasma membrane]
Stable Identifier
R-HSA-443809
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Ephrin type-B receptor 2, EPHB2_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPH receptors autophosphorylate (Homo sapiens)
EPH-ephrin oligomers [plasma membrane] (Homo sapiens)
EPHB:EFNB oligomers [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPH-ephrin mediated repulsion of cells (Homo sapiens)
Clathrin internalises EPH:EFN complexes (Homo sapiens)
EPHB:EFNB:F-actin:AP-2:Clathrrin:Dynamin [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
MMP2,9 cleave EPHB (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPH:EFN dimers tetramerise (Homo sapiens)
EPH-EFN dimers [plasma membrane] (Homo sapiens)
EPHB:EFNB dimers [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPH:EFN tetramers oligomerise (Homo sapiens)
EPH-EFN dimers [plasma membrane] (Homo sapiens)
EPHB:EFNB dimers [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPH-ephrin oligomers [plasma membrane] (Homo sapiens)
EPHB:EFNB oligomers [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs bind EFNBs (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
Ephrin signaling (Homo sapiens)
EFNB:GRB4 binds GIT1 (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EFNBs bind SDCBP (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:EFNBs:SDCBP [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EFNBs bind SFKs (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
GIT1 binds bPIX (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
PAK binds RAC and bPIX (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
PAKs autophosphorylate (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
PAKs phosphorylate MLC (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
SFKs phosphorylate EFNBs (Homo sapiens)
EPHBs:EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
SFKs phosphorylate GIT1 (Homo sapiens)
EPHBs:EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
bPIX exchanges GTP for GDP on RAC, activating it (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
p-EFNB binds GRB4 (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
L1CAM interactions (Homo sapiens)
Phosphorylation of L1 by EPHB2 (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
p-Y-L1:EPHB2 [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29323 EPHB2
Gene Names
EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5
Chain
signal peptide:1-18, chain:19-1055, chain:536-986, chain:562-986
Reference Genes
BioGPS Gene:2048 EPHB2
COSMIC (genes):EPHB2 EPHB2
CTD Gene:2048 EPHB2
dbSNP Gene:2048 EPHB2
ENSEMBL:ENSG00000133216 EPHB2
HGNC:3393 EPHB2
KEGG Gene (Homo sapiens):2048 EPHB2
Monarch:2048 EPHB2
NCBI Gene:2048 EPHB2
OMIM:600997 EPHB2
UCSC:P29323 EPHB2
Reference Transcript
RefSeq:NM_017449.4 EPHB2
RefSeq:NM_004442.7 EPHB2
RefSeq:NM_001309193.1 EPHB2
Other Identifiers
0001450131
0006510239
11723166_a_at
11723167_at
11723168_a_at
11751035_a_at
16660596
2048
2088_s_at
209588_at
209589_s_at
210651_s_at
211165_x_at
230088_at
230119_at
2324922
2324923
2324934
2324939
2324962
2324963
2324965
2324969
2324970
2324971
2324973
2324974
2324977
2324980
2324981
2324982
2324983
2324984
2324985
2324986
2324987
2324988
2324989
2324990
2324991
2324992
2324993
2324994
2324995
2324996
2324997
2324998
2655883
41678_at
46069_at
47096_at
7898809
80277_at
902_at
A_14_P136035
A_23_P200067
A_32_P406142
A_33_P3331376
A_33_P3370787
A_33_P3880302
GE480816
GE54191
GO:0000166
GO:0000902
GO:0001525
GO:0001540
GO:0001655
GO:0001933
GO:0003674
GO:0004672
GO:0004713
GO:0004714
GO:0005003
GO:0005005
GO:0005102
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0005887
GO:0006464
GO:0006468
GO:0006810
GO:0006950
GO:0007165
GO:0007169
GO:0007267
GO:0007275
GO:0007399
GO:0007411
GO:0007413
GO:0007611
GO:0007612
GO:0008046
GO:0008150
GO:0009790
GO:0009887
GO:0010628
GO:0016020
GO:0016021
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0021631
GO:0021952
GO:0022038
GO:0022607
GO:0030154
GO:0030193
GO:0030424
GO:0030425
GO:0031290
GO:0031915
GO:0032991
GO:0033674
GO:0034330
GO:0038023
GO:0040011
GO:0042472
GO:0042802
GO:0042995
GO:0043005
GO:0043025
GO:0043167
GO:0043226
GO:0043235
GO:0044877
GO:0046580
GO:0048013
GO:0048168
GO:0048170
GO:0048593
GO:0048646
GO:0048856
GO:0050770
GO:0050771
GO:0050877
GO:0050878
GO:0051389
GO:0051965
GO:0055085
GO:0060021
GO:0060996
GO:0060997
GO:0070373
GO:0071679
GO:0098794
GO:0099557
GO:0106028
GO:1900273
GO:1903078
GO:1904782
GO:1904783
Hs.125124.1.S2_3p_at
Hs.147112.0.S1_3p_at
Hs.147112.0.S2_3p_at
ILMN_1785061
ILMN_2367384
L41939_at
PH_hs_0007059
PH_hs_0018535
TC01000288.hg
TC01000291.hg
TC01004238.hg
g1100109_3p_a_at
g2739055_3p_a_at
g495677_3p_a_at
Participant Of
hasMember
EPHBs [plasma membrane]
hasComponent
p-Y-L1:EPHB2 [plasma membrane]
input
Phosphorylation of L1 by EPHB2
Other forms of this molecule
EPHB2 (?-?) [plasma membrane]
EPHB2 (?-1055) [cytosol]
EPHB2 (?-1055) [plasma membrane]
EPHB2 (19-?) [extracellular region]
p-Y596,Y602-EPHB2 [plasma membrane]
Inferred To
vab-1 [plasma membrane] (Caenorhabditis elegans)
Homologues of EPHB2 [plasma membrane] (Danio rerio)
ephb2a [plasma membrane] (Danio rerio)
EPHB2 [plasma membrane] (Bos taurus)
EPHB2 [plasma membrane] (Canis familiaris)
EPHB2 [plasma membrane] (Gallus gallus)
EPHB2 [plasma membrane] (Sus scrofa)
Ephb2 [plasma membrane] (Mus musculus)
Ephb2 [plasma membrane] (Rattus norvegicus)
Eph [plasma membrane] (Drosophila melanogaster)
Cross References
RefSeq
NP_001296122.1
,
NP_059145.2
,
NP_004433.2
ZINC - World Drugs
EPHB2_HUMAN
OpenTargets
ENSG00000133216
ZINC - FDA approved
EPHB2_HUMAN
ZINC - Substances
EPHB2_HUMAN
ZINC target
P29323
ZINC - Biogenic
EPHB2_HUMAN
PRO
P29323
PDB
3ZFM
,
1B4F
,
1F0M
,
2QBX
ZINC - Investigational
EPHB2_HUMAN
Target Pathogen
5b354852be737e166372e951
IntEnz
2.7.10.1
HPA
ENSG00000133216-EPHB2
GeneCards
P29323
Ensembl
ENSP00000383053
,
ENSP00000363763
,
ENSP00000363761
,
ENSG00000133216
,
ENST00000374632
,
ENST00000374630
,
ENST00000400191
Orphanet
15984
ZINC - Predictions - Purchasable
EPHB2_HUMAN
HMDB Protein
HMDBP01537
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49790 NUP153
1
NUP153 [nucleoplasm]
(R-HSA-157695)
0.544
2
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