Reactome: A Curated Pathway Database

Phosphorylation of L1 by EPHB2

Stable Identifier
R-HSA-443817
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

EPH kinase Cek5/EPHB2 phosphorylates tyrosine residue in the cytoplasmic domain of NgCAM/L1. The tyrosine 1229 may be the target site. EphrinB/EphB signaling enhances L1-dependent adhesion to substrates including ALCAM and extracellular matrix proteins.

Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine kinase activity of EPHB2 [plasma membrane] EPHB2 [plasma membrane] protein tyrosine kinase activity (0004713)
Inferred From