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STIP1 [cytosol]
Stable Identifier
R-HSA-443857
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Stress-induced-phosphoprotein 1, STIP1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q3SYB3 FX4L6
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Homo sapiens)
STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Homo sapiens)
STIP1 [cytosol] (Homo sapiens)
p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Homo sapiens)
STIP1 [cytosol] (Homo sapiens)
p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Homo sapiens)
STIP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P31948 STIP1
Gene Names
STIP1
Chain
chain:1-543
Reference Genes
BioGPS Gene:10963 STIP1
COSMIC (genes):STIP1 STIP1
CTD Gene:10963 STIP1
dbSNP Gene:10963 STIP1
ENSEMBL:ENSG00000168439 STIP1
HGNC:11387 STIP1
Monarch:10963 STIP1
NCBI Gene:10963 STIP1
OMIM:605063 STIP1
UCSC:P31948 STIP1
Reference Transcript
RefSeq:NM_001282652.1 STIP1
RefSeq:NM_001282653.1 STIP1
RefSeq:NM_006819.2 STIP1
Other Identifiers
10963
11743041_a_at
11743042_a_at
16726224
207_at
212009_PM_s_at
212009_s_at
213330_PM_s_at
213330_s_at
3334225
3334226
3334227
3334228
3334231
3334232
3334233
3334234
3334235
3334236
3334237
3334238
3334239
3334240
3334241
3334242
3334243
3334244
3334245
3334246
3334247
3334248
3334249
3334250
3334251
4014309
4014313
7940857
A_14_P131568
A_24_P327815
GE58119
GO:0003723
GO:0005515
GO:0005634
GO:0005737
GO:0005794
GO:0005829
GO:0032991
GO:0043226
GO:0051879
GO:0098761
GO:0101031
GO:0120293
Hs.75612.1.A1_3p_a_at
Hs.75612.2.A1_3p_a_at
ILMN_1789510
M86752_at
PH_hs_0023292
TC11000585.hg
Participates
as a member of
RND1 effectors [cytosol] (Homo sapiens)
as an output of
p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Homo sapiens)
p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Homo sapiens)
as an input of
STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Homo sapiens)
as a component of
HSP90:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
Inferred To
STI1 [cytosol]
(Saccharomyces cerevisiae)
LOC119875949 [cytosol]
(Canis familiaris)
STIP1_MOUSE [cytosol]
(Mus musculus)
Stip1 [cytosol]
(Drosophila melanogaster)
Stip1 [cytosol]
(Rattus norvegicus)
stip1 [cytosol]
(Danio rerio)
stip1 [cytosol]
(Xenopus tropicalis)
Homologues of STIP1 [cytosol]
(Dictyostelium discoideum)
sti1 [cytosol]
(Dictyostelium discoideum)
sti1 [cytosol]
(Schizosaccharomyces pombe)
STIP1 [cytosol]
(Bos taurus)
STIP1 [cytosol]
(Dictyostelium discoideum)
STIP1 [cytosol]
(Gallus gallus)
STIP1 [cytosol]
(Plasmodium falciparum)
STIP1 [cytosol]
(Sus scrofa)
sti-1 [cytosol]
(Caenorhabditis elegans)
Cross References
OpenTargets
ENSG00000168439
ENSEMBL
ENSP00000351646
,
ENSP00000445957
,
ENSP00000305958
,
ENST00000305218
,
ENST00000538945
,
ENST00000358794
HPA
ENSG00000168439-STIP1
PRO
P31948
Pharos - Targets
P31948
GlyGen
P31948
PDB
2LNI
,
3FWV
,
1ELW
,
1ELR
,
3ESK
,
7KW7
,
2NC9
Interactors (41)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P07900 HSP90AA1
8
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
0.832
7
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
0.759
6
UniProt:Q8IWD4 CC117
0.708
5
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.666
4
UniProt:Q58FF6 H90B4
0.643
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.635
3
UniProt:P53041 PPP5C
2
PPP5C [nucleoplasm]
(R-HSA-5683410)
PPP5C [cytosol]
(R-HSA-5675402)
0.623
4
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
9
UniProt:P04150 NR3C1
3
SUMO1-K277,K293-NR3C1 [nucleoplasm]
(R-HSA-4341106)
NR3C1 [cytosol]
(R-HSA-5618118)
NR3C1 [nucleoplasm]
(R-HSA-879837)
0.61
5
UniProt:O15484 CAPN5
1
CAPN5 [cytosol]
(R-HSA-8848642)
0.589
2
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.573
2
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.569
8
UniProt:Q13451 FKBP5
2
FKBP5 [nucleoplasm]
(R-HSA-8939165)
FKBP5 [cytosol]
(R-HSA-5618096)
0.564
2
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.556
3
UniProt:O95674 CDS2
1
CDS2 [mitochondrial inner membrane]
(R-HSA-1498755)
0.556
3
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.556
3
UniProt:Q06547-3 GABPB1
1
NRF2 gamma-1 subunit [nucleoplasm]
(R-HSA-1592216)
0.556
3
UniProt:Q6DHV7-2 Q6DHV72
0.556
3
UniProt:Q8IZU1 FAM9A
0.556
3
UniProt:O00423 EMAL1
0.556
3
UniProt:O00463 TRAF5
0.556
3
UniProt:P54274-2 TERF1
0.556
3
UniProt:Q14181 POLA2
1
POLA2 [nucleoplasm]
(R-HSA-68493)
0.556
3
UniProt:Q3SYB3 FX4L6
0.556
3
UniProt:Q3SXR2 CC036
0.556
3
UniProt:Q9C004 SPY4
0.556
3
UniProt:Q7Z6Z6 PNPLA5
1
PNPLA5 [cytosol]
(R-HSA-8848346)
0.527
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:O75190 DNAJB6
2
DNAJB6 [cytosol]
(R-HSA-5252014)
DNAJB6 [nucleoplasm]
(R-HSA-5255425)
0.527
2
UniProt:Q9Y6J9 TAF6L
1
TAF6L [nucleoplasm]
(R-HSA-212393)
0.527
3
UniProt:Q6UXT9 ABH15
0.527
2
UniProt:Q8N239 KLH34
0.527
2
UniProt:Q7Z6J8 UBE3D
1
UBE3D [cytosol]
(R-HSA-8851647)
0.527
3
UniProt:Q58FG0 HS905
0.527
2
UniProt:Q8N7C3 TRIMM
0.527
2
UniProt:Q58FG1 HS904
0.527
2
UniProt:Q99615 DNAJC7
2
DNAJC7 [nucleoplasm]
(R-HSA-5255408)
DNAJC7 [cytosol]
(R-HSA-5252099)
0.527
2
UniProt:Q8N1V2 CFA52
0.527
2
UniProt:Q9NYQ3 HAO2
2
HAO2 [cytosol]
(R-HSA-9033093)
HAO2 [peroxisomal matrix]
(R-HSA-6787806)
0.527
2
UniProt:Q96AP0 ACD
1
ACD [nucleoplasm]
(R-HSA-174889)
0.508
2
UniProt:Q7L3B6 CDC37L1
2
CDC37L1 [extracellular region]
(R-HSA-8848918)
CDC37L1 [platelet dense granule lumen]
(R-HSA-8848903)
0.499
2
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