SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow

Stable Identifier
R-HSA-443905
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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In a mechanism that is presumed to be analagous to signaling of SHC downstream of the insulin and TrkA receptors, SHC becomes phosphorylated and dissociates from the integrin alphaIIb beta3 complex.

Literature References
PubMed ID Title Journal Year
10964917 Identification of shc as the primary protein binding to the tyrosine-phosphorylated beta 3 subunit of alpha IIbbeta 3 during outside-in integrin platelet signaling

Cowan, KJ, Law, DA, Phillips, DR

J Biol Chem 2000
8755247 Not all Shc's roads lead to Ras

Bonfini, L, Migliaccio, E, Pelicci, G, Lanfrancone, L, Pelicci, PG

Trends Biochem Sci 1996
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Orthologous Events
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