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FZD8 [plasma membrane]
Stable Identifier
R-HSA-443947
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Frizzled-8, FZD8_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by WNT in cancer (Homo sapiens)
Signaling by RNF43 mutants (Homo sapiens)
RNF43 frameshift mutants show enhanced WNT siganling (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
FZD [plasma membrane] (Homo sapiens)
FZD8 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class B/2 (Secretin family receptors) (Homo sapiens)
Frizzled receptors bind Wnts (Homo sapiens)
Frizzled receptors [plasma membrane] (Homo sapiens)
FZD8 [plasma membrane] (Homo sapiens)
Frizzled receptors:WNTs [plasma membrane] (Homo sapiens)
Frizzled receptors [plasma membrane] (Homo sapiens)
FZD8 [plasma membrane] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
Asymmetric localization of PCP proteins (Homo sapiens)
DVL2 is phosphorylated after WNT5A binding to FZD (Homo sapiens)
WNT5A:FZD [plasma membrane] (Homo sapiens)
WNT5A-binding FZDs [plasma membrane] (Homo sapiens)
FZD8 [plasma membrane] (Homo sapiens)
WNT5A binding to FZD promotes PRICKLE1 degradation (Homo sapiens)
WNT5A-binding FZDs [plasma membrane] (Homo sapiens)
FZD8 [plasma membrane] (Homo sapiens)
WNT5A:FZD [plasma membrane] (Homo sapiens)
WNT5A-binding FZDs [plasma membrane] (Homo sapiens)
FZD8 [plasma membrane] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Regulation of FZD by ubiquitination (Homo sapiens)
USP8 deubiquitinates FZD to potentiate WNT signaling (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
FZD [plasma membrane] (Homo sapiens)
FZD8 [plasma membrane] (Homo sapiens)
ZNRF3 ubiquitinates FZD to promote its downregulation (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
FZD [plasma membrane] (Homo sapiens)
FZD8 [plasma membrane] (Homo sapiens)
ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
FZD [plasma membrane] (Homo sapiens)
FZD8 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
FZD [plasma membrane] (Homo sapiens)
FZD8 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H461 FZD8
Gene Names
FZD8
Chain
signal peptide:1-27, chain:28-694
Reference Genes
BioGPS Gene:8325 FZD8
COSMIC (genes):FZD8 FZD8
CTD Gene:8325 FZD8
dbSNP Gene:8325 FZD8
ENSEMBL:ENSG00000177283 FZD8
ENSEMBL_homo_sapiens_GENE:ENSG00000177283.8 FZD8
HGNC:4046 FZD8
KEGG Gene (Homo sapiens):8325 FZD8
Monarch:8325 FZD8
NCBI Gene:8325 FZD8
OMIM:606146 FZD8
UCSC:Q9H461 FZD8
Reference Transcript
RefSeq:NM_031866.2 FZD8
Other Identifiers
11744233_at
11758064_s_at
16713309
216587_PM_s_at
216587_s_at
224325_PM_at
224325_at
227405_PM_s_at
227405_s_at
3285129
3285130
3285131
3285132
3285133
3285134
3285135
3285136
3285137
3285138
3285139
3285140
3285141
3285142
3285143
65690_at
7933075
8325
A_23_P396858
GE79238
GO:0001525
GO:0001934
GO:0002376
GO:0004888
GO:0004930
GO:0005102
GO:0005515
GO:0005794
GO:0005886
GO:0007165
GO:0007166
GO:0007186
GO:0016020
GO:0016055
GO:0017147
GO:0023052
GO:0030154
GO:0030165
GO:0030182
GO:0031410
GO:0031625
GO:0033077
GO:0035567
GO:0036211
GO:0042813
GO:0043226
GO:0048856
GO:0060070
GO:0060089
GO:0098992
GO:1990851
HMNXSV003022378
HMNXSV003058101
Hs.302634.0.S1_3p_s_at
Hs.32659.0.A1_3p_s_at
ILMN_1729368
PH_hs_0015628
TC10001179.hg
g13623798_3p_at
g13623798_3p_x_at
Participates
as a member of
Frizzled receptors [plasma membrane] (Homo sapiens)
as a candidate of
FZD [plasma membrane] (Homo sapiens)
WNT5A-binding FZDs [plasma membrane] (Homo sapiens)
Other forms of this molecule
ub-FZD8 [plasma membrane]
Inferred To
fzd8 [plasma membrane]
(Xenopus tropicalis)
FZD8 [plasma membrane]
(Bos taurus)
FZD8 [plasma membrane]
(Canis familiaris)
FZD8 [plasma membrane]
(Mus musculus)
FZD8 [plasma membrane]
(Rattus norvegicus)
FZD8 [plasma membrane]
(Sus scrofa)
cfz-2 [plasma membrane]
(Caenorhabditis elegans)
zg05 [plasma membrane]
(Danio rerio)
fz2 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_114072.1
Guide to Pharmacology - Targets
236
OpenTargets
ENSG00000177283
HPA
ENSG00000177283-FZD8
GeneCards
Q9H461
Ensembl
ENST00000374694
,
ENSP00000363826
,
ENSG00000177283
PRO
Q9H461
Pharos - Targets
Q9H461
PDB
5UN5
,
5UN6
,
6NDZ
HMDB Protein
HMDBP07704
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P56704 WNT3A
10
WNT3A [extracellular region]
(R-HSA-201710)
N4GlycoAsn-PalmS WNT3A [extracellular exosome]
(R-HSA-3781968)
N4GlycoAsn-PalmS WNT3A [endocytic vesicle membrane]
(R-HSA-3781944)
N4GlycoAsn-PalmS WNT3A [early endosome membrane]
(R-HSA-5368483)
WNT3A [endoplasmic reticulum lumen]
(R-HSA-3238292)
N4GlycoAsn-WNT3A [endoplasmic reticulum lumen]
(R-HSA-3238231)
N4GlycoAsn-PalmS WNT3A [endoplasmic reticulum lumen]
(R-HSA-3238344)
N4GlycoAsn-PalmS WNT3A [Golgi lumen]
(R-HSA-3247832)
N4GlycoAsn-PalmS WNT3A [extracellular region]
(R-HSA-3247784)
N4GlycoAsn-PalmS WNT3A [plasma membrane]
(R-HSA-3247807)
0.499
2
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