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ACKR2 [plasma membrane]
Stable Identifier
R-HSA-443955
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
CCBP2, Chemokine-binding protein 2, CCBP2_HUMAN, D6
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
Receptor ACKR2 binds most inflammatory CC chemokines (Homo sapiens)
ACKR2 [plasma membrane] (Homo sapiens)
ACKR2:CCBP2 ligands [plasma membrane] (Homo sapiens)
ACKR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00590 ACKR2
Gene Names
ACKR2, CCBP2, CCR10, CMKBR9, D6
Chain
chain:1-384
Reference Genes
BioGPS Gene:1238 ACKR2
COSMIC (genes):ACKR2 ACKR2
COSMIC (genes):CCR10 ACKR2
CTD Gene:1238 ACKR2
dbSNP Gene:1238 ACKR2
ENSEMBL:ENSG00000144648 ACKR2
HGNC:1565 ACKR2
KEGG:hsa:1238 ACKR2
Monarch:1238 ACKR2
NCBI Gene:1238 ACKR2
OMIM:602648 ACKR2
UCSC:O00590 ACKR2
Reference Transcript
RefSeq:NM_001296.4 ACKR2
Other Identifiers
11731715_at
11731716_at
1238
1568850_PM_at
1568850_at
206887_PM_at
206887_at
239452_PM_at
239452_at
2619479
2619481
2619483
2619484
2619485
2619486
2619490
2619498
2619499
2619500
2619501
2619502
2619506
2619507
2619508
2619509
2619510
2619511
2619512
2619517
2619518
32484_at
43210_r_at
51863_at
8079117
A_14_P124305
A_23_P91954
GE59590
GO:0002376
GO:0004930
GO:0004950
GO:0005044
GO:0005515
GO:0005654
GO:0005768
GO:0005769
GO:0005829
GO:0005884
GO:0005886
GO:0006935
GO:0006954
GO:0006955
GO:0007165
GO:0007186
GO:0007204
GO:0009897
GO:0016020
GO:0016192
GO:0016493
GO:0019722
GO:0019957
GO:0031410
GO:0031965
GO:0035556
GO:0038024
GO:0043226
GO:0043231
GO:0048870
GO:0055037
GO:0060089
GO:0060326
GO:0070098
HMNXSV003028564
Hs.24286.0.A1_3p_at
Hs2.395764.1.S1_3p_at
ILMN_1763127
PH_hs_0028814
TC03002310.hg
g4502910_3p_at
Participates
as a component of
ACKR2:CCBP2 ligands [plasma membrane] (Homo sapiens)
as an input of
Receptor ACKR2 binds most inflammatory CC chemokines (Homo sapiens)
Inferred To
npr-32 [plasma membrane]
(Caenorhabditis elegans)
ACKR2 [plasma membrane]
(Bos taurus)
ACKR2 [plasma membrane]
(Gallus gallus)
ACKR2 [plasma membrane]
(Sus scrofa)
Ackr2 [plasma membrane]
(Mus musculus)
Ackr2 [plasma membrane]
(Rattus norvegicus)
Cross References
Guide to Pharmacology - Targets
314
ENSEMBL
ENST00000442925
,
ENST00000422265
,
ENSP00000396150
,
ENSP00000416996
OpenTargets
ENSG00000144648
HPA
ENSG00000144648-ACKR2
PRO
O00590
Pharos - Targets
O00590
GlyGen
O00590
PDB
8GO9
,
8J8Z
,
8J8V
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q0D2K0 NIPAL4
1
NIPAL4 [plasma membrane]
(R-HSA-5216046)
0.556
3
UniProt:Q9NRX6 KISHB
0.556
3
UniProt:P11836 CD20
0.556
3
UniProt:P52803 EFNA5
3
EFNA5 (21-?) N-ter [extracellular region]
(R-HSA-3928456)
EFNA5 (?-203) C-ter [plasma membrane]
(R-HSA-3928431)
EFNA5 [plasma membrane]
(R-HSA-2682331)
0.556
3
UniProt:P48165 GJA8
1
GJA8 [endoplasmic reticulum membrane]
(R-HSA-190702)
0.556
3
UniProt:Q9UKG4 SLC13A4
1
SLC13A4 [plasma membrane]
(R-HSA-433098)
0.556
3
UniProt:Q9NTJ5 SACM1L
2
SACM1L [endoplasmic reticulum membrane]
(R-HSA-1604637)
SACM1L [Golgi membrane]
(R-HSA-1806242)
0.556
3
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